Manjuraj T, G Krishnamurthy, Yadav D. Bodke, H.S. Bhojya Naik, Mohammed Shafeeulla
Manjuraj T1, G Krishnamurthy1*, Yadav D. Bodke2, H.S. Bhojya Naik2, Mohammed Shafeeulla1
1Department of Chemistry, Sahyadri Science College (Auto), Shimoga, Karnataka India.
2Department of Post Graduation Studies in Industrial Chemistry, Jnanasahyadri, Kuvempu, University, Shankaraghatta, Karnataka India.
Volume - 10,
Issue - 4,
Year - 2017
A new mannich base ligand N'-(1H-benzimidazol-1-ylmethyl) pyridine-4-carbohydrazide (BI) formed by the condensation of benzimidazole and Isoniazid (INH), the complexes of [CoCl2(BI)2], [Ni (BI)2]Cl2, and [CuCl2(BI)2] have been synthesized and characterized by elemental analysis, conductivity measurements, 1H NMR, mass, FTIR, UV–Visible, and magnetic susceptibility. The Powder XRD studies suggested that monoclinic for [CoCl2(BI)2], [CuCl2(BI)2] complexes and orthorhombic for [Ni(BI)2]Cl2complex. The resultsofantioxidant activity indicating that the complexes have excellent modes of DPPH radical scavenging inhibition, the molecular docking studies were performed to evaluate the binding energy interactions by 3MNG human antioxidant protein receptor binds to selective amino acid residues with ligand (BI) and the metal complexes.
Cite this article:
Manjuraj T, G Krishnamurthy, Yadav D. Bodke, H.S. Bhojya Naik, Mohammed Shafeeulla. Co(II), Ni(II) and Cu(II) complexes of new Mannich base of of N'-(1H-benzimidazol-1-ylmethyl) Pyridine-4-Carbohydrazide: Spectral, XRD, Molecular Docking, Antioxidant and Antimicrobial Studies. Asian J. Research Chem. 2017; 10(4):470-476. doi: 10.5958/0974-4150.2017.00076.1