ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): GVH Raju, S Ganapathy, DG Sankar, PY Naidu

Email(s): gadepalli_raj@yahoo.com

DOI: Not Available

Address: GVH Raju*, S Ganapathy, DG Sankar and PY Naidu
Orchid Healthcare, SIPCOT Industrial Park, B3-B6, Irungattukottai, Sriperumbudur
Kancheepuram District-602105
*Corresponding Author

Published In:   Volume - 2,      Issue - 3,     Year - 2009


ABSTRACT:
An isocratic reversed phase liquid chromatographic (RP-HPLC) method has been developed and subsequently validated for the determination of Levetiracetam in bulk and pharmaceutical formulation. Separation was achieved with a Hypersil Gold 150 x 4.6mm;5µ column with Mixture of Potassium Dihydrogen Phosphate and Sodium 1-Heptane Sulphonate(pH adjusted to 2.8±0.05 with Orthophosphoric acid):Acetonitrile(90:10,v/v) as eluent at a flow rate 1.0 ml/min. UV detection was performed at 220nm.The method is simple, rapid, selective and stability indicating .The described method is linear over a range of 43.444µg/mL to 289.629µg/mL.The method precision for the determination of assay was below 1.0% RSD .The Percentage recoveries of Active Pharmaceutical Ingredient(API) from dosage forms ranged from 100.2 to 101.0.The method is useful in the quality control of bulk manufacturing and also in pharmaceutical formulations.


Cite this article:
GVH Raju, S Ganapathy, DG Sankar, PY Naidu. RP-HPLC Determination of Levetiracetam in Bulk and Pharmaceutical Formulation. Asian J. Research Chem. 2(3): July-Sept. 2009 page 253-257.


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