ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): R. Vijayalakshmi, S. Anbazhagan

Email(s): skmoumita@gmail.com

DOI: Not Available

Address: R. Vijayalakshmi and S. Anbazhagan
1Department of Pharmaceutical analysis, Gautham College of Pharmacy (Affiliated to Rajiv Gandhi University of Health Sciences), R.T. Nagar post, Bangalore, Karnataka -560032
2Karuna college of Pharmacy (Affiliated to Kerala University of Health Sciences), Irringuttur, Thirumittacode P.O. Palakad Dist. Kerala-679533.
*Corresponding Author

Published In:   Volume - 4,      Issue - 9,     Year - 2011


ABSTRACT:
A simple, selective, rapid and precise RP-HPLC has been developed for the simultaneous estimation of Metamizole sodium and Pitofenone HCl in presence of Fenpiverinium bromide of combined Pharmaceutical dosage forms. The Inertsil ODS 3V C-18 Column was used for Metamizole sodium and Pitofenone HCL separation. The Mobile phase used was sodium dihydrogen phosphate buffer : Methanol,(0.05M, pH 5.0), (53:47 v/v) at a flow rate of 1ml/min at 286nm. The calibration curves was linear at a concentration range of 700.90 µg/ml to1301.73 µg/ml and 7.01µg/ml to 13.01µg/ml with its regression coefficient (r2=0.9992 and 0.9995) for Metamizole sodium and Pitofenone HCl respectively was obtained. The LOD and LOQ was found to be in the range of 21.6174 µg/ml and 65.507 µg/ml for Metamizole sodium and 0.1701µg/ml and 0.5155 µg/ml for Pitofenone HCl respectively. The method is highly sensitive and successfully applied for determination of Metamizole sodium and Fenpiverinium bromide in tablet dosage forms.


Cite this article:
R. Vijayalakshmi, S. Anbazhagan. Method Development and Validation for Simultaneous Estimation of Metamizole Sodium and Pitofenone HCl by a Stability Indicating RP-HPLC. Asian J. Research Chem. 4(9): Sept, 2011; Page 1371-1377.


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