Tentu Nageswara Rao, Muralidhar Reddy Avuthu, B. Venkata Reddy, SNVS Murthy
Tentu Nageswara Rao1*, Muralidhar Reddy Avuthu2, B. Venkata Reddy3, SNVS Murthy4
1Department of Chemistry, Krishna University, Machilipatnam, A.P., India.
2Department of Chemistry, SVKP & Dr. K.S Raju Arts & Science College, Penugonda, A.P, India.
3Department of Animal Science, Chonbuk National University, Jeonju, South Korea.
4Department of Chemistry, DLR PG College, G. Mamidada, AP India.
Volume - 9,
Issue - 11,
Year - 2016
A simple and inexpensive method was developed with high performance liquid chromatography with PDA detection for determination of Terbinafine HCl and related impurities. The chromatographic separations were achieved on (150×4.6 mm), 5.0 µm make: YMC-Pack ODS-AM, 120A column employing Acetonitrile: methanol and Water pH 7.5, in the ratio of 20:10:10 v/v/v as mobile phase with gradient programmed at flow rate 1.0 mL/min was chosen. Three impurities were eluted within 35 minutes. The detector wavelength of 230 nm was employed.
Cite this article:
Tentu Nageswara Rao, Muralidhar Reddy Avuthu, B. Venkata Reddy, SNVS Murthy. Forced degradation study of Terbinafine HCl by HPLC with PDA detector. Asian J. Research Chem. 2016; 9(11): 561-565. doi: 10.5958/0974-4150.2016.00076.6