ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Yogeshwar Reddy M*, Ramesh V, Kista Reddy Ch, Venugopal N, Saravanan G, Suresh Y, Suryanarayana M, Debashish Datta, Raju B

Email(s): yogeshwarreddy@yahoo.com

DOI: Not Available

Address: Yogeshwar Reddy M1,3*, Ramesh V2, Kista Reddy Ch3, Venugopal N1, Saravanan G1, Suresh Y1, Suryanarayana M1, Debashish Datta1 and Raju B2: 1Matrix Laboratories Ltd., R and D centre, Jinnaram Mandal, Medak, 502325, India. 2National Centre for Mass Spectrometry, Indian Institute of Chemical Technology, Hyderabad, 500 007, India. 3Department of Chemistry, P.G. College of Science, Saifabad, Hyderabad, India. *Corresponding Author

Published In:   Volume - 3,      Issue - 2,     Year - 2010


ABSTRACT:
A Liquid chromatographic (LC) method using mass spectrometric (MS) detection was developed and validated for the trace analysis (ppm level) of 4-Bromo methyl-2'-Cyanobiphenyl in Valsartan drug substances. LC analysis of 4-Bromo methyl-2'-Cyanobiphenyl was done on Necleosil C18 (100 mm x 4.6 mm, 3 µm) column and the mobile phase is in the ratio of 50:50:1 containing water, acetonitrile, and acetic acid. The flow rate was 1.0 mL min-1 and the elution was monitored at 225 nm. The method was validated as per International Conference on Harmonization (ICH) guidelines. LC-MS is able to quantitate up to 1.0 ppm of 4-Bromo methyl-2'-cyanobiphenyl.


Cite this article:
Yogeshwar Reddy M*, Ramesh V, Kista Reddy Ch, Venugopal N, Saravanan G, Suresh Y, Suryanarayana M, Debashish Datta, Raju B. Low-Level Determination of Residual 4-Bromo Methyl-2'-Cyanobiphenyl in Valsartan by Liquid Chromatography-Mass Spectrometry. Asian J. Research Chem. 3(2): April- June 2010; Page 407-410.


Recomonded Articles:

Asian Journal of Research in Chemistry (AJRC) is an international, peer-reviewed journal devoted to pure and applied chemistry..... Read more >>>

RNI: Not Available                     
DOI: 10.5958/0974-4150 

Popular Articles


Recent Articles




Tags