ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Y. A. Jaliwala, Rahul Chaturvedi, Arvind Rathore, Amit Pandit, P.K. Mohanty

Email(s): jaliwala_y@rediffmail.com

DOI: Not Available

Address: Y. A. Jaliwala1*,Rahul Chaturvedi1,Arvind Rathore1,Amit Pandit2 and P.K. Mohanty1
1VNS Institute of Pharmacy, Bhopal, (MP), India.
2School of Pharmacy, Devi Ahilya Vishwavidyalaya, Indore
*Corresponding Author

Published In:   Volume - 4,      Issue - 11,     Year - 2011


ABSTRACT:
2-Acetoxybenzoic acid suffers from the general side effects of NSAIDs, owing to presence of free carboxylic acid group. The study was aimed to retard the adverse effects of gastrointestinal origin. 4 prodrugs of 2-Acetoxybenzoic acid were synthesized by amidation with ethyl esters of amino acids, namely, glycine, L-phenylalanine, L-glutamic acid, L-aspartic acid. Puri?ed synthesized prodrugs were characterized by m.p., TLC, solubility, elemental analyses, UV, FTIR, NMR. Synthesized prodrugs were subjected for Antypyretic, Analgesic, Anti-in?ammatory activities and Ulcerogenic index. Marked reduction of ulcerogenic index and comparable Antypyretic, Analgesic, Anti-in?ammatory activities were obtained in all cases as compared to 2-Acetoxybenzoic acid.


Cite this article:
Y. A. Jaliwala,Rahul Chaturvedi, Arvind Rathore, Amit Pandit, P.K. Mohanty. Synthesis and Evaluation of Prodrug of 2-Acetoxybenzoic Acid with Amino-Acids. Asian J. Research Chem. 4(11): Nov., 2011; Page 1695-1700.

Cite(Electronic):
Y. A. Jaliwala,Rahul Chaturvedi, Arvind Rathore, Amit Pandit, P.K. Mohanty. Synthesis and Evaluation of Prodrug of 2-Acetoxybenzoic Acid with Amino-Acids. Asian J. Research Chem. 4(11): Nov., 2011; Page 1695-1700.   Available on: https://ajrconline.org/AbstractView.aspx?PID=2011-4-11-9


Recomonded Articles:

Author(s): Syed Tasleem Hussain, Gul Abad Khan, Muhammad Shabeer

DOI:         Access: Open Access Read More

Author(s): Bhavna V. Mohite

DOI:         Access: Open Access Read More

Author(s): Prathima Patil, S.P. Sethy, T. Sameena, K. Shailaja

DOI:         Access: Open Access Read More

Author(s): Gullipilli Sandhya, R. Ravichandra Babu

DOI: 10.5958/0974-4150.2018.00115.3         Access: Open Access Read More

Author(s): Mukesh K. Nagar, Karishma R. Waghmare, P.N. Dhabale, Pradeep D. Chanekar, Suresh Bhatia

DOI:         Access: Open Access Read More

Author(s): Kishu Tripathi

DOI:         Access: Open Access Read More

Author(s): Suha K. Al-Mosawi, Hanan A. Al-Hazam, Abbas F. Abbas

DOI: 10.5958/0974-4150.2019.00031.2         Access: Open Access Read More

Author(s): Kateryna Taran, Ayaou Abderrahim, Vera Kravchenko, Olena Novosel, Svitlana Taran

DOI: 10.5958/0974-4150.2020.00034.6         Access: Open Access Read More

Author(s): Ravi N. Patel, Urviben Y. Patel, Kiran M. Patel, Jimit S. Patel, Ankit D. Patel, Dhrubo Jyoti Sen

DOI:         Access: Open Access Read More

Author(s): Vikram R. Jadhav

DOI: 10.5958/0974-4150.2020.00043.7         Access: Open Access Read More

Author(s): P. Valentina, K. Ilango, Deepak Jain, Prerna Shukla

DOI:         Access: Open Access Read More

Author(s): Chavan Pooja Ajit, Avinash Mahadeo Bhagwat, Atul Prabhakar Chaudhari

DOI: 10.52711/0974-4150.2021.00061         Access: Open Access Read More

Author(s): A. A. Kulkarni, S. R. Doshi, R. K. Nanda, N. R. Chatterjee

DOI:         Access: Open Access Read More

Author(s): Mukund Nagarnaik, Arun Sarjoshi, Ajay Bodkhe, Bhupendra Khanal, Mayuri Pise, Girish Pandya

DOI: 10.5958/0974-4150.2015.00102.9         Access: Open Access Read More

Asian Journal of Research in Chemistry (AJRC) is an international, peer-reviewed journal devoted to pure and applied chemistry..... Read more >>>

RNI: Not Available                     
DOI: 10.5958/0974-4150 

Popular Articles


Recent Articles




Tags