ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Rachana Rani, Sudeep Mishra

Email(s): rachana.chemistry@gmail.com

DOI: Not Available

Address: Rachana Rani1* and Sudeep Mishra2
1Division of Medicinal Chemistry, Central Drug Research Institute, Lucknow
2National Institute of Science Communication and Information Resources, Dr. K. S.Krishnan Marg, New Delhi
*Corresponding Author

Published In:   Volume - 4,      Issue - 7,     Year - 2011


ABSTRACT:
Diaryl heptanoid based ketene dithioacetals have been synthesized in good yield by the condensation of aromatic aldehyde or substituted aromatic aldehyde and acetone ketene dithioacetals in the presence of methanolic potassium hydroxide, 3,4-dihydro-2H-pyran, PPTS as a catalyst under room temperature conditions. It is the first suceesful report of utility of potassium hydroxide as a base for the preparation of series of ketene. a- oxo ketene dithioacetals have been extensively used as the anti-leishmanial agent. The remarkable advantages offered by this method are excellent catalyst, mild reaction conditions, simple procedure and good yield of product.


Cite this article:
Rachana Rani, Sudeep Mishra. Synthesis of Diaryl Heptanoid Based Ketene Dithioacetals as Novel Antileishmanial Agents. Asian J. Research Chem. 4(7): July, 2011; Page 1188-1193.


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RNI: Not Available                     
DOI: 10.5958/0974-4150 

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