ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): M. Shankar, N.L. Gowrishankar, S. Narendiran, K. Sudhakar

Email(s): shankarmanichellappa@gmail.com

DOI: Not Available

Address: M. Shankar*, N.L. Gowrishankar, S. Narendiran and K. Sudhakar
Department of Pharmaceutical Chemistry, Swami Vivekanandha Institute of Pharmaceutical Sciences, Vangapally (V), Yadhagirigutta (M), Nalgonda (District), Pin - 508286, Andhra Pradesh.
*Corresponding Author

Published In:   Volume - 5,      Issue - 1,     Year - 2012


ABSTRACT:
The protein-ligand interaction plays a significant role in the structural based drug designing. In our research work we have taken the cyclo-oxygenase receptor (COX). The receptor was docked to the commercially available NSAID (Non Steroid Anti Inflammatory Drugs) Celecoxib and Naproxen Protein Structure Modeling Method, using INSIGHTII software. We tried to improve the binding efficiency and steric compatibility of Celecoxib and Naproxen against COX receptor. Several modifications were made to the probable functional groups which were interacting with receptor molecule. Analogs of the drug molecule were prepared using MODELLER9v1chemsketch and docked using INSIGHT II docking software. The modified drugs was sketched using chemsketch were found to be better than the convectional drugs available. Further from this work we can improve the steric compatibility and then Absorption, Distribution, Metabolism and Excretion (ADME) properties of the analogs can be analyzed using Insilco ADME tools.


Cite this article:
M. Shankar, N.L. Gowrishankar, S. Narendiran, K. Sudhakar. Denovo Design of the Lead against Cyclo-Oxygenase Receptor. Asian J. Research Chem. 5(1): January 2012; Page 38-43.


Recomonded Articles:

Author(s): R Siva Kumar, Shaik Nafeez Basha, P Kumar Nallasivan, WD Sam Solomon, R Venkatnarayanan

DOI:         Access: Open Access Read More

Author(s): R Narendra Kumar, G Nageswara Rao, PY Naidu

DOI:         Access: Open Access Read More

Author(s): M. Shankar, N.L. Gowrishankar, S. Narendiran, K. Sudhakar

DOI:         Access: Open Access Read More

Asian Journal of Research in Chemistry (AJRC) is an international, peer-reviewed journal devoted to pure and applied chemistry..... Read more >>>

RNI: Not Available                     
DOI: 10.5958/0974-4150 

Popular Articles


Recent Articles




Tags