ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): R Narendra Kumar, G Nageswara Rao, PY Naidu

Email(s): narenrokkam@yahoo.co.in

DOI: Not Available

Address: R Narendra Kumar*, G Nageswara Rao and PY Naidu
*Corresponding Author

Published In:   Volume - 3,      Issue - 2,     Year - 2010


ABSTRACT:
An isocratic stability indicating liquid chromatographic method has been developed and validated for the determination of Eszopiclone in bulk drug and its pharmaceutical dosage form. Separation of the drug with degradation products was achieved using Peerless HT, C8, 50 x 4.6 mm; 1.8 µm column as stationary phase and pH 4.5(±0.05) buffer: Acetonitrile: Tetrahydrofuran (81:18:1,v/v) as mobile phase at a flow rate of 1.0 mL/min. UV detection was performed at 304 nm. The method is linear over the range of 10 - 150 µg/mL. The percent recovery of drug in dosage forms was ranged from 97.7 to 100.5. The method is simple, rapid, precise, selective and stability indicating and can be used for the assay in quality control and stability studies samples.


Cite this article:
R Narendra Kumar, G Nageswara Rao, PY Naidu. Stability Indicating RP-LC Method for Determination of Eszopiclone in Bulk and Pharmaceutical Dosage Forms. Asian J. Research Chem. 3(2): April- June 2010; Page 374-379.


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