ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Naveen Kadian, Meenaxi Maste, A.R. Bhat

Email(s): naveen20.a@gmail.com

DOI: Not Available

Address: Naveen Kadian*, Meenaxi Maste and A.R. Bhat
Department of Pharmaceutical Chemistry, KLEU’s College of Pharmacy, Belgaum, Karnataka, India.
*Corresponding Author

Published In:   Volume - 5,      Issue - 3,     Year - 2012


ABSTRACT:
Compound .{(3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl)acetic acid.} and .{(6-chloro-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl)acetic acid.} was synthesized by reacting O-Amino Phenol and Maleic Anhydride. Futher eight Mannich Bases were synthesized by using substituted Aromatic Amines. The structures of Synthesized compounds were confirmed on basis of IR, NMR and Mass Spectra. All synthesized compounds were screened for their Antibacterial Activity against strains viz . E. coli, Staphylococcus aureus, Bacillus sps, Pseudomonas , K.Pneumonea and E. Faecalis. Compounds [3-oxo-4-{[(4-(N-(2-pyridyl)sulfamoyl)phenyl) amino]methyl}-3,4-dihydro-2H-1,4-benaoxazin-2-yl] acetic acid, [3-oxo-4-{[(4-(N-(5-methyl-1,2-oxazol-3-yl)sulfamoyl) phenyl) amino]methyl}-3,4-dihydro-2H-1,4-benaoxazin-2-yl] acetic acid, [6-chloro-3-oxo-4-{[4-(N-(2-pyridyl)sulfamoylmethyl)phenyl]amino} methyl}-3,4-dihydro-2H-1,4-benzoxazin 2-yl]acetic acid,[6-chloro-3-oxo-4-{[(4-(N-(5-methyl-1,2-oxazol-3-yl) sulfamoylmethyl)phenyl)amino]methyl}-3,4-dihydro-2H-1,4-benzoxazin-2-yl]acetic acid showed good activity against the K .pneumonea and E. faecalis, compounds [3-oxo-4-{[(4-(N-(5-methyl-1,2-oxazol-3-yl)sulfamoyl) phenyl) amino]methyl}-3,4-dihydro-2H-1,4-benaoxazin-2-yl] acetic acid, [6-chloro-3-oxo-4-{[(4-(N-(5-methyl-1,2-oxazol-3-yl) sulfamoylmethyl)phenyl)amino]methyl}-3,4-dihydro-2H-1,4-benzoxazin-2-yl]acetic acid showed good activity against the S.aureas, while other compound showed moderate activity against E. coli, klebeseila , Staphy. aureus, E. fecalis. While other derivative shown moderate antibacterial activity.


Cite this article:
Naveen Kadian, Meenaxi Maste, A.R. Bhat. Synthesis and Evaluation of Antibacterial Activity of 1, 4-Benzoxazine Analogues. Asian J. Research Chem. 5(3): March 2012; Page 365-370.


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