Synthesis of two novel impurities in the manufacturing process of Paroxetine.HCl. ½H2O is described. They were characterized by spectroscopic techniques like 1HNMR, 13CNMR and MS. Synthesis and reaction mechanism is also explained in details.
Cite this article:
Ramesh Yamgar, Sudhir Sawant. Synthesis and characterization of novel impurities in Paroxetine Hydrochloride hemihydrate and adopting QbD principles to built in quality in process of final drug substance. Asian J. Research Chem. 5(3): March 2012; Page 329-335.