ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): D.M.Darandale, K.B. Erande, S.R. Tambe, R.S. Bhamber

Email(s): d.darandale@gmail.com

DOI: 10.5958/0974-4150.2017.00121.3   

Address: D.M.Darandale1, K.B. Erande1, S.R. Tambe2, R.S. Bhamber3
1Department of Quality Assurance Techniques, MGV’s PharmacyCollege, Panchvati, Nashik, Maharashtra, India. 422002.
2Department of Pharmaceutical Chemistry, MGV’s Pharmacy College, Panchvati, Nashik, Maharashtra, India. 422002.
3Department of Pharmacognosy, SPH College of Pharmacy, Malegaon, Nashik, Maharashtra, India.
*Corresponding Author

Published In:   Volume - 10,      Issue - 6,     Year - 2017


ABSTRACT:
The objective of the present work was to develop a simple and accurate RP-HPLC method for the estimation of febuxostat in bulk and pharmaceutical dosage forms, using grace C18 (250mm x 4.6ID, Particle size: 5 micron) in isocratic mode, with mobile phase Methanol: PotassiumDi- Hydrogen Phosphate10mM Buffer pH:6.8 (70:30). The flow rate was 0.8 ml/min and the detection was monitored by UV detector at 315nm. The retention time for febuxostat was found to be 7.08 min. The proposed method has permitted the quantification of febuxostat over linearity in the range of 10-50 µg/ml and its percentage recovery was found to be 99.72%. The intraday and inter day precision were found 0.13 % and 0.35 %, respectively.


Cite this article:
D.M.Darandale, K.B. Erande, S.R. Tambe, R.S. Bhamber. Development and Validation of RP-HPLC Method for the Determination of Febuxostat in Bulk and Pharmaceutical Dosage Form. Asian J. Research Chem. 2017; 10(6):713-718. doi: 10.5958/0974-4150.2017.00121.3


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