ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Srishyalam. Vadde, Devanna. N, Shiva Rama Krishna. S, Sreenivasulu R, Naveen Mulakayala

Email(s): shailam.vadde@gmail.com

DOI: 10.5958/0974-4150.2018.00130.X   

Address: Srishyalam. Vadde 1, Devanna. N1, Shiva Rama Krishna. S2, Sreenivasulu R2, Naveen Mulakayala3
1Department of Chemistry, Jawaharlal Nehru Technological University Anantapur, Ananthapuramu, Andhra Pradesh, India.
2Mewar University, Gangrar, Chittorgarh, Rajasthan-312901
3Clearsynth Labs Ltd. IDA Mallapur, Nacharam, Hyderabad-500076, India.
*Corresponding Author

Published In:   Volume - 11,      Issue - 4,     Year - 2018


ABSTRACT:
A simple, convenient and efficient method for the synthesis of 5-aryl/alkyl pyrazolo[4,3-d]pyrimidin-7(6H)-ones from 4-amino-1-methyl-3-propylpyrazole-5-carboxamide by the condensation of aldehydes under mild and neutral reaction conditions using N-bromosuccinamide (NBS)as oxidantwith good yields and high selectivity in single step which have potential applications in medicinal chemistry.


Cite this article:
Srishyalam. Vadde , Devanna. N, Shiva Rama Krishna. S, Sreenivasulu R, Naveen Mulakayala. N-Bromosuccinamide (NBS) mediated construction of pharmacologically important 5-Substituted pyrazolo[4,3-d]pyrimidin-7(6H)-ones. Asian J. Research Chem. 2018; 11(4):739-745. doi: 10.5958/0974-4150.2018.00130.X


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Asian Journal of Research in Chemistry (AJRC) is an international, peer-reviewed journal devoted to pure and applied chemistry..... Read more >>>

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DOI: 10.5958/0974-4150 

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