Author(s):
Srishyalam. Vadde, Devanna. N, Shiva Rama Krishna. S, Sreenivasulu R, Naveen Mulakayala
Email(s):
shailam.vadde@gmail.com
DOI:
10.5958/0974-4150.2018.00130.X 
Address:
Srishyalam. Vadde 1, Devanna. N1, Shiva Rama Krishna. S2, Sreenivasulu R2, Naveen Mulakayala3
1Department of Chemistry, Jawaharlal Nehru Technological University Anantapur, Ananthapuramu,
Andhra Pradesh, India.
2Mewar University, Gangrar, Chittorgarh, Rajasthan-312901
3Clearsynth Labs Ltd. IDA Mallapur, Nacharam, Hyderabad-500076, India.
*Corresponding Author
Published In:
Volume - 11,
Issue - 4,
Year - 2018
ABSTRACT:
A simple, convenient and efficient method for the synthesis of 5-aryl/alkyl pyrazolo[4,3-d]pyrimidin-7(6H)-ones from 4-amino-1-methyl-3-propylpyrazole-5-carboxamide by the condensation of aldehydes under mild and neutral reaction conditions using N-bromosuccinamide (NBS)as oxidantwith good yields and high selectivity in single step which have potential applications in medicinal chemistry.
Cite this article:
Srishyalam. Vadde , Devanna. N, Shiva Rama Krishna. S, Sreenivasulu R, Naveen Mulakayala. N-Bromosuccinamide (NBS) mediated construction of pharmacologically important 5-Substituted pyrazolo[4,3-d]pyrimidin-7(6H)-ones. Asian J. Research Chem. 2018; 11(4):739-745. doi: 10.5958/0974-4150.2018.00130.X
Cite(Electronic):
Srishyalam. Vadde , Devanna. N, Shiva Rama Krishna. S, Sreenivasulu R, Naveen Mulakayala. N-Bromosuccinamide (NBS) mediated construction of pharmacologically important 5-Substituted pyrazolo[4,3-d]pyrimidin-7(6H)-ones. Asian J. Research Chem. 2018; 11(4):739-745. doi: 10.5958/0974-4150.2018.00130.X Available on: https://ajrconline.org/AbstractView.aspx?PID=2018-11-4-8