Srishyalam. Vadde, Devanna. N, Shiva Rama Krishna. S, Sreenivasulu R, Naveen Mulakayala
Srishyalam. Vadde 1, Devanna. N1, Shiva Rama Krishna. S2, Sreenivasulu R2, Naveen Mulakayala3
1Department of Chemistry, Jawaharlal Nehru Technological University Anantapur, Ananthapuramu,
Andhra Pradesh, India.
2Mewar University, Gangrar, Chittorgarh, Rajasthan-312901
3Clearsynth Labs Ltd. IDA Mallapur, Nacharam, Hyderabad-500076, India.
Volume - 11,
Issue - 4,
Year - 2018
A simple, convenient and efficient method for the synthesis of 5-aryl/alkyl pyrazolo[4,3-d]pyrimidin-7(6H)-ones from 4-amino-1-methyl-3-propylpyrazole-5-carboxamide by the condensation of aldehydes under mild and neutral reaction conditions using N-bromosuccinamide (NBS)as oxidantwith good yields and high selectivity in single step which have potential applications in medicinal chemistry.
Cite this article:
Srishyalam. Vadde , Devanna. N, Shiva Rama Krishna. S, Sreenivasulu R, Naveen Mulakayala. N-Bromosuccinamide (NBS) mediated construction of pharmacologically important 5-Substituted pyrazolo[4,3-d]pyrimidin-7(6H)-ones. Asian J. Research Chem. 2018; 11(4):739-745. doi: 10.5958/0974-4150.2018.00130.X