0974-4150 (Online)
0974-4169 (Print)

Author(s): Sameer Dixit, Arun K. Sikarwar


DOI: 10.5958/0974-4150.2020.00046.2   

Address: Sameer Dixit1, Arun K. Sikarwar2
1Department of Chemistry, M. J. P. Govt. Polytechnic College Khandwa, Madhya Paradesh (India).
2Department of Chemistry, Govt. Home Science P. G. College Hoshangabad, Madhya Paradesh (India).
*Corresponding Author

Published In:   Volume - 13,      Issue - 3,     Year - 2020

A Quantitative Structure-Property relationship (QSPR) model was developed for prediction of Activity of Phenol’s and its congeners against L1210 Leukaemia cells. Murine cell lines such as P388 leukemia, L1210 leukemia, and B16 melanoma, dominated the early years of cancer cell testing both in culture and in mice. In this study we have attempted to develop a multiple linear regression (MLR) model with high accuracy and precision. For this first we prepare several models and then validate them by statistical parameters like Q Factor, PE, PSE, SPRESS etc. and proposed a model which has better prediction power to prediction of Activity against L1210 Leukaemia cells.

Cite this article:
Sameer Dixit, Arun K. Sikarwar. Statistical Approach to Modelling of Activity of Phenol’s and its Derivatives against L1210 Leukaemia cells. Asian J. Research Chem. 2020; 13(3):237-240. doi: 10.5958/0974-4150.2020.00046.2

1.    Selassie and colleagues, J Med Chem, 48, 7234, (2005)
2.    Nandi S. l., Vracko M., Bagchi M. C., Anticancer activity of selected phenolic compounds: QSAR studies using ridge regression and neural networks, Chem Biol Drug Des, 70(5), 424-36, (2007)
3.    Haghi, A.K. Methodologies and Applications for Chemoinformatics and Chemical Engineering, IGI Global, 2, (2013)
4.    Richon A. B., An Introduction to QSAR Methodology, Network Science Corporation, 5, (2018)
5.    Pogliani L., Structure Property Relationships of Amino Acids and Some Dipeptides, Amino Acids, 6,141-153, (1994)
6.    Rishikesh V. Antre, Rajesh J. Oswal, et al., QSAR Studies of Substituted Pyrazolone Derivatives as AntiInflammatory Agents, Med chem, 2(6): 126-130 (2012)
7.    J. H. van Drie, Curr. Pharm.Des. 2003, 9, 1649.
8.    J. H. van Drie, in: Computational Medicinal Chemistry for Drug Discovery, P. Bultinck et al., Eds., Marcel Dekker, 2004.
9.    H. Meyer, Arch. Exp. Pathol. Pharmakol. 1999, 42, 109.
10.    A. Golbraikh, A. Tropsha, J. Mol.Graph Mod. 2002, 20, 269.
11.    A. Tropsha, P. Gramatica, V.J. Gombar, QSAR Comb. Sci., 2003, 22, 69.
12.    P. Gramatica, Principles of QSAR models validation: internal and external, QSAR Comb.Sci.2007, 26(5), 694-701.

Recomonded Articles:

Author(s): Gullipilli Sandhya, R. Ravichandra Babu

DOI: 10.5958/0974-4150.2018.00115.3         Access: Open Access Read More

Author(s): Syed Tasleem Hussain, Gul Abad Khan, Muhammad Shabeer

DOI:         Access: Open Access Read More

Author(s): Kateryna Taran, Ayaou Abderrahim, Vera Kravchenko, Olena Novosel, Svitlana Taran

DOI: 10.5958/0974-4150.2020.00034.6         Access: Closed Access Read More

Author(s): Mukesh K. Nagar, Karishma R. Waghmare, P.N. Dhabale, Pradeep D. Chanekar, Suresh Bhatia

DOI:         Access: Open Access Read More

Author(s): Bhavna V. Mohite

DOI:         Access: Open Access Read More

Author(s): Ram C. Senwar, Krishna K. Rathore, Anita Mehta

DOI: 10.5958/0974-4150.2017.00022.0         Access: Open Access Read More

Author(s): Virupakshi Prabhakar, Kondra Sudhakar Babu, L.K. Ravindranath, M. Sahanoor Basha, J. Latha

DOI: 10.5958/0974-4150.2017.00012.8         Access: Open Access Read More

Author(s): Arun Kumar, Vinita Gupta, Sanchita Singh, Y.K. Gupta

DOI: 10.5958/0974-4150.2017.00038.4         Access: Open Access Read More

Author(s): Prathima Patil, S.P. Sethy, T. Sameena, K. Shailaja

DOI:         Access: Open Access Read More

Author(s): Bulusu Lakshmi Sushma1, Gutta Madhusudhan, Anireddy Jayashree

DOI: 10.5958/0974-4150.2017.00014.1         Access: Open Access Read More

Author(s): Y. Padmavathi, Akari Anjali, Nayaka Raghavendra Babu, P Ravi Kumar

DOI: 10.5958/0974-4150.2017.00064.5         Access: Open Access Read More

Author(s): Tauseef Shaikh, Atar Mujum , Khan Wasimuzzama, Rukhsana A Rub

DOI:         Access: Open Access Read More

Asian Journal of Research in Chemistry (AJRC) is an international, peer-reviewed journal devoted to pure and applied chemistry..... Read more >>>

RNI: Not Available                     
DOI: 10.5958/0974-4150 

Popular Articles

Recent Articles