Author(s):
Prem Kumar, Reneesh Jaiswal, Rajesh Meshram, Dheeraj Ahirwar
Email(s):
yprem173@gmail.com
DOI:
10.52711/0974-4150.2026.00016 
Address:
Prem Kumar*, Reneesh Jaiswal, Rajesh Meshram, Dheeraj Ahirwar
School of Pharmacy, Chouksey Engineering College Bilaspur, Chhattisgarh, India.
*Corresponding Author
Published In:
Volume - 19,
Issue - 2,
Year - 2026
ABSTRACT:
The escalating global crisis of antimicrobial resistance (AMR) necessitates the urgent development of novel therapeutic agents. Carbazole, a privileged scaffold in medicinal chemistry, is known for its diverse biological activities. This study aimed to synthesize and characterize novel carbazole-based hydrazide derivatives and evaluate their antibacterial potential. Two target compounds, 2-(2-chloro-9H-carbazol-9-yl) acetohydrazide (IIIa) and 2-(3-bromo-9H-carbazol-9-yl) acetohydrazide (IIIb), were synthesized via a two-step procedure involving N-alkylation of substituted carbazoles with ethyl chloroacetate, followed by hydrazinolysis. The structures of the synthesized compounds were unequivocally confirmed using sophisticated spectroscopic techniques, including FTIR and ¹H NMR. The compounds were obtained in good yields (68-76%) and exhibited sharp melting points, indicating high purity. In-vitro antibacterial screening against Staphylococcus aureus (Gram-positive) and Pseudomonas aeruginosa (Gram-negative) strains revealed promising activity. Compound IIIa (Cl-substituted) showed superior potency with Minimum Inhibitory Concentration (MIC) values of 12µg/mL and 9µg/mL, respectively, compared to IIIb (Br-substituted) with MICs of 18µg/mL and 16µg/mL. The results establish a preliminary structure-activity relationship, indicating that the nature and position of the halogen substituent significantly influence antibacterial efficacy. These findings position these novel carbazole hydrazides as promising lead compounds for the development of new antimicrobial agents to combat drug-resistant bacteria.
Cite this article:
Prem Kumar, Reneesh Jaiswal, Rajesh Meshram, Dheeraj Ahirwar. Synthesis, Spectroscopic Characterization and In-Vitro Antimicrobial Evaluation of New Hydrazide-Functionalized Carbazole Derivatives. Asian Journal of Research in Chemistry.2026; 19(2):97-0. doi: 10.52711/0974-4150.2026.00016
Cite(Electronic):
Prem Kumar, Reneesh Jaiswal, Rajesh Meshram, Dheeraj Ahirwar. Synthesis, Spectroscopic Characterization and In-Vitro Antimicrobial Evaluation of New Hydrazide-Functionalized Carbazole Derivatives. Asian Journal of Research in Chemistry.2026; 19(2):97-0. doi: 10.52711/0974-4150.2026.00016 Available on: https://ajrconline.org/AbstractView.aspx?PID=2026-19-2-3
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