Akshay R. Yadav, Shrinivas K. Mohite, Chandrakant S. Magdum
Akshay R. Yadav*, Shrinivas K. Mohite, Chandrakant S. Magdum
Department of Pharmaceutical Chemistry, Rajarambapu College of Pharmacy, Kasegaon, Maharashtra, India-415404.
Volume - 13,
Issue - 4,
Year - 2020
The microwave assisted organic reaction comes under green chemistry proved to be eco-friendly and higher yield. In present article we performed some organic reactions using microwave irradiation. This green processes have resulted through use of less or no catalyst, readily recyclable solvents and yield that are often higher than conventional method. Microwave heating produces heat in entire material in the same rate and the same time at a high speed and at a high rate of reaction. Microwave assisted synthesis has become an important tool to the medicinal chemist for rapid organic synthesis. The microwave reactions were performed using microwave assisted synthesis on microwave, the reactions were worked up extensively to obtain a pure form of product which was isolated using literature work-up procedures. The products were further recrystallized with suitable solvents. The reactions were monitored with TLC intermittently for microwave assisted synthesis and hourly for conventional method of synthesis.
Cite this article:
Akshay R. Yadav, Shrinivas K. Mohite, Chandrakant S. Magdum. Microwave assisted synthesis of some Traditional reactions: Green chemistry approach. Asian J. Research Chem. 2020; 13(4):275-278. doi: 10.5958/0974-4150.2020.00053.X
1. Surati M, Jauhari S, Desai K, A brief review: Microwave assisted organic reaction. Arch. Appl. Sci. Res., 2012, 4(1):645-661.
2. Yadav A, Mohite S, Magdum C, Synthesis, Characterization and Biological Evaluation of Some Novel 1,3,4-Oxadiazole Derivatives as Potential Anticancer Agents, Int J Sci Res Sci Technol. March-April-2020; 7 (2) : 275-282.
3. A KNagariya, A K Meena, A K Yadav, U S Niranjan, A K Pathak, B Singh, M MRao, Microwave assisted organic reaction as new tool in organic synthesis. J Pharm. Res. 2010, 3(3), 575-580.
4. Gaba M, Dhingra N, Microwave chemistry: General features and applications. Ind J Pharm Edu Res, 2011, 45(2): 175-183.
5. Gedye R, Smith F, WestawayK, The use of microwave ovens for rapid organic synthesis. Tetrahedron Lett1986; 27: 279-282.
6. Rajak H, Mishra P. Microwave assisted combinatorial chemistry: The potential approach for acceleration of drug discovery. J Sci Indus Res 2004; 63:641-654.
7. Langa F, Cruz P, Hoz A, Ortiz A, Barra E. Microwave irradiation: more than just a method for accelerating reactions. Comtemp Org Synth 1997; 4: 373-386.
8. Yadav A, Mohite S, Design, Synthesis and Characterization of Some Novel benzamide derivatives and it’s Pharmacological Screening. 2020. Int J Sci Res Sci Technol. 7(2): 68-74.
9. Gupta M, Paul S, Gupta R. General characteristics and applications of microwave in organic synthesis. ActaChimSlov 2009; 56: 749-764.
10. Wilson N S, Sarko CR, Roth GP: Development and applications of a practical continuous flow microwave cell. Org Proc Res Dev 2004; 535-538.
11. Rajput M. D, Yadav A. R, Mohite S.K, Synthesis, Characterization of Benzimidazole Derivatives as Potent Antimicrobial Agents. 2020. Int. J. Pharm. 17(4): 279-285.
12. Joshi U J, Gokhale K M, Kantikar A P, Green chemistry: need for the hour, Ind. J. Edu. Res. 2011; 168-174.
13. Gasgnier M, Loupy A, Petit A, Jullien H, New developments in the field of energy transfer by means of monomade microwaves for various oxides and hydroxides. J. Alloys Comp. 1994; 204: 165-72.
14. Elander N, Jones JR, Lu SY, Stone-Elander S. Microwave-enhanced radiochemistry. ChemSoc Rev 2000;29;239-249.
15. A. Tiwari, R. Kumar, A practical book of pharmaceutical medicinal chemistry. Nirali prakashan:11.\Furniss B. S, Hanford A. J., Vogel’s textbook of practical chemistry, 5ed. Pearson education: 1989. P.1162-1163.
16. Gavarkar P. S, C. S. Magdum, S. K. Mohite, R. S. Adnaik, Practical’s in Medicinal chemistry, 1ed. Unicorn publication: 32-33.