ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Lincy Joseph, Mathew George

Email(s): mathewlincg@yahoo.com

DOI: Not Available

Address: Lincy Joseph* and Mathew George
School of Pharmacy, Jaipur National University, Jaipur, Rajasthan, India
*Corresponding Author

Published In:   Volume - 2,      Issue - 3,     Year - 2009


ABSTRACT:
Objective of the study was to synthesize (E)-3-arylidene flavanones by one pot method and to screen synthesized compounds for their analgesic and anti-oxidant activities. A set of four (E)-3 arylidene flavanones were synthesized by simple base catalyzed condensation of appropriate aryl aldehydes and 2’-hydroxy acetophenone. Analgesic activity screened by hot plate method and anti-oxidant activity evaluated by spectrophotometrically using 2,2-diphenyl-1-picrylhydrazyl (DPPH) . Results indicated that only compound I, II, and III were showed remarkable analgesic activity while compound IV didn’t exhibited analgesic activity at all, but compound IV exhibited maximum anti- oxidant activity. Due to structural similarity with those of natural flavanones, all the synthesized compounds were expected to exhibit analgesic activity, but only three were found to exhibit analgesic action. But all exhibited anti-oxidant activity.


Cite this article:
Lincy Joseph, Mathew George. Analgesic and Anti-Oxidant Activities of Certain (E)-3 Arylidene Flavanones Synthesized by One Pot Method. Asian J. Research Chem. 2(3): July-Sept., 2009, page 318-321.


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