ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): B. Pochaiah, C.P. Meher, B. Srujana, P. Swarnalatha, A.Muralidhar Rao

Email(s): balu14886@gmail.com

DOI: Not Available

Address: B. Pochaiah*, C.P. Meher, B. Srujana, P. Swarnalatha, A.Muralidhar Rao
Maheshwara Institute of Pharmacy, Chitkul, Patancheru, Medak, A.P
*Corresponding Author

Published In:   Volume - 6,      Issue - 1,     Year - 2013


ABSTRACT:
Benzotriazole (I) has been prepared by reacting ortho phenylene diamine with Sodium nitrite in presence of glacial acetic acid at 850 OC. N1-ethylacetate derivative of Benzotriazole (II) was synthesized by reacting the Benzotriazole (I) with ethyl chloroacetate in dry acetone solvent and in presence of anhydrous Potassium carbonate. N-Hydrazine hydrate derivative of Benzotriazole (III) were synthesized by reacting the ethylacetate derivative of Benzotriazole with hydrazine hydrate. Newly synthesized Benzotriazole derivatives of Aromatic Aldehydes (IVc,d) and aromatic ketones (IVa,b ) were prepared by reacting the Hydrazine hydrate derivative of Benzotriazole with 4-OH Benzaldehyde, N, N -dimethyl amino Benzaldehyde, Acetophenone and benzophenone in methanol and these synthesized compounds were confirmed by IR and NMR spectras. Which were purified by recrystallisation and column chromatography. The conformed compounds were evaluated for anticonvulsant activity using phenytoin as standard by MES method.


Cite this article:
B. Pochaiah, C.P. Meher, B. Srujana, P. Swarnalatha, A.Muralidhar Rao. Synthesis of Some Novel Benzotriazole-1-yl-acetic acid substituted aryl hydrazide Derivatives as Anticonvulsant Agents. Asian J. Research Chem. 6(1): January 2013; Page 71-75.

Cite(Electronic):
B. Pochaiah, C.P. Meher, B. Srujana, P. Swarnalatha, A.Muralidhar Rao. Synthesis of Some Novel Benzotriazole-1-yl-acetic acid substituted aryl hydrazide Derivatives as Anticonvulsant Agents. Asian J. Research Chem. 6(1): January 2013; Page 71-75.   Available on: https://ajrconline.org/AbstractView.aspx?PID=2013-6-1-15


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