Hemant Badwaik, Sandeep Sonkar, Mukesh Singh, Suresh Rajpal, Dharamveer Sisodiya, Ajit Pandey
Hemant Badwaik*, Sandeep Sonkar, Mukesh Singh, Suresh Rajpal, Dharamveer Sisodiya and Ajit Pandey
Ultra College of Pharmacy, Madurai, Tamil Nadu
Volume - 2,
Issue - 4,
Year - 2009
The present work deals with synthesis and evaluation of some novel phenylthiazole and quinazoline combination derivatives of biological interest. The reaction of acetophenone with thiourea formed 4-phenylthiazol-2-amine (I) was refluxed with N-chloroacetyl anthranillic acid (II)in the presence of K2CO3 in dry ethanol under anhydrous condition yields 2-chloromethyl-3-[4-(phenyl)thiazol-2-yl]-quinazolin -4(3H)one(III).The 2-chloromethyl-3-[4-(phenyl)thiazol-2-yl]quinazolin-4(3H)–one(III) and respective aromatic amines was refluxed in dry pyridine and acetic anhydride formed N-3-[ 4-( 4–phenyl ) thiazol–2–yl ]-[ 2-( substituted amino) methyl ] quinazoline–4 (3H)-one derivatives (IV).The synthesized compounds are to be screened for antibacterial activity.
Cite this article:
Hemant Badwaik, Sandeep Sonkar, Mukesh Singh, Suresh Rajpal, Dharamveer Sisodiya, Ajit Pandey. Synthesis and Antibacterial Evaluation of Some Novel Phenylthiazolyl-Quinqzolin-4(3h)-One Derivative. Asian J. Research Chem. 2(4):Oct.-Dec. 2009 page 544-546.