ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Hemant Badwaik, Sandeep Sonkar, Mukesh Singh, Suresh Rajpal, Dharamveer Sisodiya, Ajit Pandey

Email(s): ssonkar12@gmail.com

DOI: Not Available

Address: Hemant Badwaik*, Sandeep Sonkar, Mukesh Singh, Suresh Rajpal, Dharamveer Sisodiya and Ajit Pandey
Ultra College of Pharmacy, Madurai, Tamil Nadu

Published In:   Volume - 2,      Issue - 4,     Year - 2009


ABSTRACT:
The present work deals with synthesis and evaluation of some novel phenylthiazole and quinazoline combination derivatives of biological interest. The reaction of acetophenone with thiourea formed 4-phenylthiazol-2-amine (I) was refluxed with N-chloroacetyl anthranillic acid (II)in the presence of K2CO3 in dry ethanol under anhydrous condition yields 2-chloromethyl-3-[4-(phenyl)thiazol-2-yl]-quinazolin -4(3H)one(III).The 2-chloromethyl-3-[4-(phenyl)thiazol-2-yl]quinazolin-4(3H)–one(III) and respective aromatic amines was refluxed in dry pyridine and acetic anhydride formed N-3-[ 4-( 4–phenyl ) thiazol–2–yl ]-[ 2-( substituted amino) methyl ] quinazoline–4 (3H)-one derivatives (IV).The synthesized compounds are to be screened for antibacterial activity.


Cite this article:
Hemant Badwaik, Sandeep Sonkar, Mukesh Singh, Suresh Rajpal, Dharamveer Sisodiya, Ajit Pandey. Synthesis and Antibacterial Evaluation of Some Novel Phenylthiazolyl-Quinqzolin-4(3h)-One Derivative. Asian J. Research Chem. 2(4):Oct.-Dec. 2009 page 544-546.


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Asian Journal of Research in Chemistry (AJRC) is an international, peer-reviewed journal devoted to pure and applied chemistry..... Read more >>>

RNI: Not Available                     
DOI: 10.5958/0974-4150 

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