Asian Journal of Research in Chemistry

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0974-4150 (Online)
0974-4169 (Print)


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Synthesis and Biological Evaluation of Amides of Aminothiazole Derivatives

Author(s): AK Prajapati, Vishal P Modi

Email(s): akprajapati@yahoo.co.uk

DOI: Not Available

Address: AK Prajapati* and Vishal P Modi
Department of Applied Chemistry, Faculty of Technology and Engineering, The M. S. University of Baroda, Vadodara-390 001, India
*Corresponding Author

Published In:   Volume - 3,      Issue - 1,     Year - 2010

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ABSTRACT:
Condensation of acetophenone with thiourea in presence of Iodine gives 2-amino-4-phenylthiazole (I). 4-(2-Amino-4-phenyl-thiazol-5-yl-azo)-benzoic acid ethyl ester (III) was prepared by coupling of 4-ethoxycarbonylphenyldiazonium chloride with 2-amino-4-phenylthiazole. A series of amide (V) can be synthesized by treatment of appropriate substituted acid chlorides with compound (III) using pyridine as solvent. All the synthesized compounds are characterized by the combination of elemental analysis and standard spectroscopic method. They are screened for anti-bacterial activity against Escherichia coli and Staphylococcus aureus as well as screened for antifungal activity against aspergillus niger and apergillus oryzae by cup plate method at 1µg/mL concentration in DMF. All the synthesized compounds showed moderate or good microbial activity.


Keywords:

Cite this article:
AK Prajapati, Vishal P Modi. Synthesis and Biological Evaluation of Amides of Aminothiazole Derivatives. Asian J. Research Chem. 3(1): Jan.-Mar. 2010; Page 121-125.

Cite(Electronic):
AK Prajapati, Vishal P Modi. Synthesis and Biological Evaluation of Amides of Aminothiazole Derivatives. Asian J. Research Chem. 3(1): Jan.-Mar. 2010; Page 121-125.   Available on: https://ajrconline.org/AbstractView.aspx?PID=2010-3-1-31


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Asian Journal of Research in Chemistry (AJRC) is an international, peer-reviewed journal devoted to pure and applied chemistry..... Read more >>>

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Asian Journal of Research in Chemistry (AJRC) (ISSN: print-0974-4169, Online-0974-4150) is an international, peer-reviewed journal devoted to pure and applied chemistry. AJRC publishes Original Research Articles, Short Communications, Review Articles in all aspects of chemistry. Topics covered including the traditional areas of analytical, inorganic, organic, biochemistry, forensic, physical-theoretical chemistry as well as newer interdisciplinary areas such as agriculture, materials science, computational, medicine, spectroscopy, polymers, supramolecular, surface, chemical physics, biological, medicinal/ drugs, environmental and pharmaceutical chemistry.
The journal is published quarterly every year in last week of March, June, September and December. From January 2011, is monthly and shall be published every year in last week of Month.    
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