Sanjib Das, RC Das, SH Bhosale, Ashish A Gawai
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Sanjib Das1*, RC Das2, SH Bhosale2 and Ashish A Gawai1
1.Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh, Assam- 7861004, India
2.Poona College of Pharmacy, Bharti Vidyapeeth University, Pune-411038, India
Volume - 3,
Issue - 1,
Year - 2010
A new series of coumarinaoacetamides (3a-h) have been synthesized by refluxing various chloroacetamides (2a-h) with 7-hydroxy-4-methyl chromen-2-one (1) in acetonitrile and anhydrous K2CO3. The chloroacetamides have been prepared from the chloroacetyl chloride with various substituted amines. The synthesized compounds have been characterized with the help of spectral and analytical data. The title compounds were screened for their antipsychotics activity in terms of their ability to inhibit apomorphine induced climbling behaviour in albino Swiss mice. All the compounds showed significant activity.
Cite this article:
Sanjib Das, RC Das, SH Bhosale, Ashish A Gawai. Synthesis and Pharmacological Evaluation of Atypical Antipsychotic Activity of New Coumarinoacetamides. Asian J. Research Chem. 3(1): Jan.-Mar. 2010; Page 166-171.