ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Gawai Ashish, Das Sanjib, Nemade M, Wathore S.

Email(s): ashishgawai82@gmail.com , dr_sanjib@sify.com

DOI: Not Available

Address: Gawai Ashish1*, Das Sanjib1, Nemade M2 and Wathore S.2
1Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh, Assam- 786004, India
2TVES’s College of Pharmacy, Nehru Vidyanagar, Faizpur, M.S-425503, India.
*Corresponding Author

Published In:   Volume - 4,      Issue - 4,     Year - 2011


ABSTRACT:
A new series of 7-(3-(benzo[d]thiazol-2-ylamino)propoxy)-4-methyl-2H-chromen-2-one derivatives(4a-4k) were synthesized and evaluated for their D2 and 5HT2 antagonistic activity as a measure of atypical antipsychotic property. Most of these compounds showed dopamine D2 receptor antagonistic activity from moderate to high potency along with serotonin 5-HT2 receptor blockage activity. The dopamine D2 and serotonin 5-HT2 receptor blockage activity was evaluated by inhibition of apomorphine-induced climbing behavior and 5HTP induced head twitches in mice respectively. Compounds 7-(3-(benzo[d]thiazol-2-ylamino)propoxy)-4-methyl-2H-chromen-2-one derivatives (4a-4k) were synthesized by addition of various 2-amino benzothiazoles substituted derivatives (3a-3k) with 7-(3-Chloropropoxy)-4-methyl-2H-chromen-2-one(2) refluxing in dry pyridine. The synthesized compounds were characterized with the help of spectral and analytical study.


Cite this article:
Gawai Ashish, Das Sanjib, Nemade M, Wathore S.. Synthesis of New 7-(3-(benzo[d]thiazol-2-ylamino) propoxy)-4-methyl-2H-chromen-2-one derivatives with Atypical Antipsychotic activity. Asian J. Research Chem. 4(4): April, 2011; Page 591-596.


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Asian Journal of Research in Chemistry (AJRC) is an international, peer-reviewed journal devoted to pure and applied chemistry..... Read more >>>

RNI: Not Available                     
DOI: 10.5958/0974-4150 

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