Yogesh Jadhav, Kushal Dawane, Vrushali Patil, A.S. Bobade, S.V. Athlekar, Abhay Chowdhary
Yogesh Jadhav, Kushal Dawane, Vrushali Patil, A.S. Bobade, S.V. Athlekar and Abhay Chowdhary
Department of Chemotherapy, Haffkine Institute for Training, Research and Testing, Acharya Donde Marg, Parel, Mumbai-400012
Volume - 3,
Issue - 4,
Year - 2010
The 3-Hydroxy pyridine on reaction with ethylchloro acetate in presence of K2CO3 followed by the reaction with hydrazine hydrate resulted in the formation of 3-pyridoxy acetyl hydrazide (III), which on further the reaction with CS2 and KOH cyclized to give (IV) which on reaction with different acid chloride form 2-(3-pyridoxymethyl)-5-(4-substitutedphenyl)-1,3,4-triazole. These structures are determined by the elemental analysis and spectral data (IR, 1H-NMR). These new derivatives are evaluated for in vitro antimicrobial activity against Staphylococcus aureus (ATCC 3750), Salmonella typhi (NCTC 786), Candida albicans (ATCC 10231) and Aspergillus niger (ATCC 16404).
Cite this article:
Yogesh Jadhav, Kushal Dawane, Vrushali Patil, A.S. Bobade, S.V. Athlekar, Abhay Chowdhary. Synthesis and Biological Evaluation of New Pyridine Derivatives. Asian J. Research Chem. 3(4): Oct. - Dec. 2010; Page 955-957.