ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): T.V. Yuvaraj, S. Hurmath Unnissa, N.S.Surendiran, M. Azeez Ur rahman, V.Binumon

Email(s): rx_yuva@yahoo.co.in , rx.yuva@gmail.com

DOI: Not Available

Address: T.V.Yuvaraj1*, S. Hurmath Unnissa2, N.S.Surendiran3, M.Azeez Ur rahman4 and V.Binumon4
1Mother Theresa Post Graduate and Research Institute of Health Sciences, Puducherry, India-605006
2Department of Chemistry, KMCH College of Pharmacy, Coimbatore, Tamilnadu, India-641035
3Department of Biotechnology, HITS College of pharmacy, Hyderabad
4KMCH College of Pharmacy, Coimbatore, Tamilnadu, India-641035
*Corresponding Author

Published In:   Volume - 3,      Issue - 4,     Year - 2010


ABSTRACT:
Cinnoline is a nitrogenous organic base obtained from certain complex diazo compounds. It is an isosteric, relative to either quinoline or iso quinoline. Cinnoline itself is toxic and shows antibacterial activity against Escherichia coli. None of its derivatives have been found in nature. Its condensed bicyclic aromatic heterocycle contains two nitrogen atoms. Sulphamido group is introduced into cinnoline nucleus to get compounds with enhanced potency. Pyrazolocinnolines are obtained by diazotization of sulphanilamide followed by coupling to form corresponding hydrazones which, on intramolecular cyclisation forms 3-acetyl-6- sulphamido-cinnolin-4-ones [CN-I]. Further, treatment with hydrazine hydrate yields the expected 3’-methyl-6-sulphamido-1’substituted-pyrazolo [4, 3-C] cinnoline derivatives. The compounds were characterized by analytical techniques like TLC, UV, IR, NMR Spectral studies. Screening for antimicrobial activity against bacterial organisms like Escherichia coli, Klebsiella aurogeniosea, Micrococcus luteus, Bacillus cereus and fungal organism like Candida albicans using Disc Diffusion Method were performed.


Cite this article:
T.V. Yuvaraj, S. Hurmath Unnissa, N.S.Surendiran, M. Azeez Ur rahman, V.Binumon. Synthesis and Antimicrobial Screening of Some Novel Cinnoline Derivatives. Asian J. Research Chem. 3(4): Oct. - Dec. 2010; Page 853-858.


Recomonded Articles:

Author(s): Virupakshi Prabhakar, Kondra Sudhakar Babu, L.K. Ravindranath, M. Sahanoor Basha, J. Latha

DOI: 10.5958/0974-4150.2017.00012.8         Access: Open Access Read More

Author(s): Ram C. Senwar, Krishna K. Rathore, Anita Mehta

DOI: 10.5958/0974-4150.2017.00022.0         Access: Open Access Read More

Author(s): Arun Kumar, Vinita Gupta, Sanchita Singh, Y.K. Gupta

DOI: 10.5958/0974-4150.2017.00038.4         Access: Open Access Read More

Author(s): Bhavna V. Mohite

DOI:         Access: Open Access Read More

Author(s): Bulusu Lakshmi Sushma1, Gutta Madhusudhan, Anireddy Jayashree

DOI: 10.5958/0974-4150.2017.00014.1         Access: Open Access Read More

Author(s): Tauseef Shaikh, Atar Mujum , Khan Wasimuzzama, Rukhsana A Rub

DOI:         Access: Open Access Read More

Author(s): Y. Padmavathi, Akari Anjali, Nayaka Raghavendra Babu, P Ravi Kumar

DOI: 10.5958/0974-4150.2017.00064.5         Access: Open Access Read More

Author(s): Pankaj Baboo, Girendra Gautam, S.K. Gupta

DOI: 10.5958/0974-4150.2017.00039.6         Access: Open Access Read More

Author(s): Virupakshi Prabhakar, Kondra Sudhakar Babu, L.K. Ravindranath, J. Latha, B.Venkateswarlu

DOI: 10.5958/0974-4150.2017.00011.6         Access: Open Access Read More

Author(s): Sushil Kumar Dubey, Amla Batra

DOI:         Access: Open Access Read More

Author(s): Prathima Patil, S.P. Sethy, T. Sameena, K. Shailaja

DOI:         Access: Open Access Read More

Asian Journal of Research in Chemistry (AJRC) is an international, peer-reviewed journal devoted to pure and applied chemistry..... Read more >>>

RNI: Not Available                     
DOI: 10.5958/0974-4150 

Popular Articles


Recent Articles




Tags