Priya R. Modiya, Urviben Y. Patel, Ravi N. Patel, Dhrubo Jyoti Sen
Priya R. Modiya, Urviben Y. Patel, Ravi N. Patel and Dhrubo Jyoti Sen
Department of Pharmaceutical Chemistry, Shri Sarvajanik Pharmacy College, Gujarat Technological University, Arvind Baug, Mehsana-384001, Gujarat, India
Volume - 4,
Issue - 1,
Year - 2011
Biological macromolecules are composed of one or more linear oligomers that fold into a functional form. The information that governs the final structure is encoded in the sequence of monomers and the precise functionality that they display, but accurate prediction of such structures remains a major challenge in structural biology. Recently, chemists have begun to develop small molecule systems that fold in a similar way and these may help to answer more complex questions or find applications in artificial molecular assemblies. Study of the properties of a family of oligoamides composed of alternating repeats of isophthalic acid and bisaniline building blocks have a rich supramolecular chemistry in non-polar solvents, forming macrocyclic receptors, catenanes, knots and double-stranded zipper complexes via a combination of amide–amide hydrogen bonds and aromatic interactions. Here the serendipitous discovery of a new member of the family that folds into a well-defined, compact, three-dimensional structure, governed by a combination of hydrogen bonding and aromatic interactions.
Cite this article:
Priya R. Modiya, Urviben Y. Patel, Ravi N. Patel, Dhrubo Jyoti Sen. Foldamers are Artificial Molecular Architectures Inspired by Biopolymers which can hold the Molecules in the Matrix by Non-Covalent Interactions. Asian J. Research Chem. 4(1): January 2011; Page 13-23.