ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Sachan Dinesh, Pandeya S.N., Pathak A.K

Email(s): sachan1771@gmail.com

DOI: Not Available

Address: Sachan Dinesh*, Pandeya S.N. and Pathak A.K.
Department of Pharmaceutical Sciences, Saroj Institute of Technology and Management, Lucknow.
*Corresponding Author

Published In:   Volume - 4,      Issue - 9,     Year - 2011


ABSTRACT:
The purine analogues are new class of nonclassical antimicrobial agents that binds with riboswitches. Purine (adenine) analogues are having antimicrobial, antifungal, antitumour, antiproliferative, antiviral and activity against HSV-1. Riboswitches are structured RNA domains that can bind directly to speci?c ligands and regulate gene expression. These RNA elements are located most commonly within the non-coding regions of bacterial mRNAs, because these genes were involved in fundamental metabolic pathways in certain bacterial pathogens. Purine-binding riboswitches may be targets for the development of novel antimicrobial agents. Designed compounds are bound by a purine riboswitches aptamer in vitro with af?nities comparable to that of the natural ligand, and several also inhibit microbial growth.


Keywords:

Cite this article:
Sachan Dinesh, Pandeya S.N., Pathak A.K. Various Methods for Synthesis of Purine Analogues. Asian J. Research Chem. 4(9): Sept, 2011; Page 1361-1365.


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