The purine analogues are new class of nonclassical antimicrobial agents that binds with riboswitches. Purine (adenine) analogues are having antimicrobial, antifungal, antitumour, antiproliferative, antiviral and activity against HSV-1. Riboswitches are structured RNA domains that can bind directly to speci?c ligands and regulate gene expression. These RNA elements are located most commonly within the non-coding regions of bacterial mRNAs, because these genes were involved in fundamental metabolic pathways in certain bacterial pathogens. Purine-binding riboswitches may be targets for the development of novel antimicrobial agents. Designed compounds are bound by a purine riboswitches aptamer in vitro with af?nities comparable to that of the natural ligand, and several also inhibit microbial growth.
Cite this article:
Sachan Dinesh, Pandeya S.N., Pathak A.K. Various Methods for Synthesis of Purine Analogues. Asian J. Research Chem. 4(9): Sept, 2011; Page 1361-1365.