Asian Journal of Research in Chemistry

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0974-4150 (Online)
0974-4169 (Print)


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Various Methods for Synthesis of Purine Analogues

Author(s): Sachan Dinesh, Pandeya S.N., Pathak A.K

Email(s): sachan1771@gmail.com

DOI: Not Available

Address: Sachan Dinesh*, Pandeya S.N. and Pathak A.K.
Department of Pharmaceutical Sciences, Saroj Institute of Technology and Management, Lucknow.
*Corresponding Author

Published In:   Volume - 4,      Issue - 9,     Year - 2011

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ABSTRACT:
The purine analogues are new class of nonclassical antimicrobial agents that binds with riboswitches. Purine (adenine) analogues are having antimicrobial, antifungal, antitumour, antiproliferative, antiviral and activity against HSV-1. Riboswitches are structured RNA domains that can bind directly to speci?c ligands and regulate gene expression. These RNA elements are located most commonly within the non-coding regions of bacterial mRNAs, because these genes were involved in fundamental metabolic pathways in certain bacterial pathogens. Purine-binding riboswitches may be targets for the development of novel antimicrobial agents. Designed compounds are bound by a purine riboswitches aptamer in vitro with af?nities comparable to that of the natural ligand, and several also inhibit microbial growth.


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Cite this article:
Sachan Dinesh, Pandeya S.N., Pathak A.K. Various Methods for Synthesis of Purine Analogues. Asian J. Research Chem. 4(9): Sept, 2011; Page 1361-1365.

Cite(Electronic):
Sachan Dinesh, Pandeya S.N., Pathak A.K. Various Methods for Synthesis of Purine Analogues. Asian J. Research Chem. 4(9): Sept, 2011; Page 1361-1365.   Available on: https://ajrconline.org/AbstractView.aspx?PID=2011-4-9-2


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Asian Journal of Research in Chemistry (AJRC) (ISSN: print-0974-4169, Online-0974-4150) is an international, peer-reviewed journal devoted to pure and applied chemistry. AJRC publishes Original Research Articles, Short Communications, Review Articles in all aspects of chemistry. Topics covered including the traditional areas of analytical, inorganic, organic, biochemistry, forensic, physical-theoretical chemistry as well as newer interdisciplinary areas such as agriculture, materials science, computational, medicine, spectroscopy, polymers, supramolecular, surface, chemical physics, biological, medicinal/ drugs, environmental and pharmaceutical chemistry.
The journal is published quarterly every year in last week of March, June, September and December. From January 2011, is monthly and shall be published every year in last week of Month.    
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