Sreenu Thalla, Jyothibasu Tammu, Subba Reddy Thalla
Sreenu Thalla1*, Jyothibasu Tammu1, Subba Reddy Thalla2
1Department of Pharmacology, A.S.N Pharmacy College, Tenali, Andhra Pradesh, India
2Department of biotechnology, S.K. University, Ananthapur, Andhra Pradesh, India
Volume - 5,
Issue - 12,
Year - 2012
Male Swiss albino mice weighing about 25-30g were taken and amnesia was induced by injecting Streptozotocin (STZ) on 1 and 3 days (3mg/kg) bilaterally. After 5 days of injection the animals were treated with 100mg/kg and 200mg/kg (p.o) of Ocimum gratissimum (OG) extract for 2 weeks. Various behavioural parameters like Elevated plus Maze, Passive shock avoidance, Y-Maze tests were performed. Ocimum gratissimum improved learning and memory of mice as indicated by decreased transfer latency, increased step-down latency and increase in percentage alteration. Ocimum gratissimum extract has shown decreased levels of Acetylcholine esterase enzyme. The methanolic extract of the plant possessed anti-amnesic property at a dose level.
Cite this article:
Sreenu Thalla, Jyothibasu Tammu, Subba Reddy Thalla. Nootropic activity of Ocimum gratissimum in Streptozotocin induced Amnesia. Asian J. Research Chem. 5(12): Dec., 2012; Page 1437-1439.