Author(s):
Babaso V. Udugade, Shivaji P. Gawade
Email(s):
swarajudugade@gmail.com
DOI:
10.5958/0974-4150.2018.00033.0 
Address:
Babaso V. Udugade1*, Shivaji P. Gawade2
1Department of Medicinal Chemistry, Satara College of Pharmacy, Degaon, Satara- 415004 Maharashtra India
2Department of Pharmacology, Sahyadri College of Pharmacy, Methawade, Sangola- 413307, Maharashtra, India
*Corresponding Author
Published In:
Volume - 11,
Issue - 1,
Year - 2018
ABSTRACT:
We reported the synthesis and type- II anti-diabetic activity of pyrrolidine-2-carbonitrile derived ligands in SHR-STZ animal models. 3 Dimensional Quantitative Structural activity, pharmacophore, docking studies used for design of molecules, studies reveled that novel substituted cyanopyrrolidines had been promising candidate for further research. Molecules had been synthesized and evaluated for anti-diabetic activity through the use of Spontaneously Hypertensive Rat- Streptozotocin animal model. Amongst all of the synthesized compounds 1-(2-(5- methylisoxazol-3-ylamino) acetyl) pyrrolidine-2-carbonitrile, 1- (2-(5-methyl-1, 2, 4-oxadiazol-3-ylamino) acetyl) pyrrolidine-2- carbonitrile and 1-(2-(1, 2, 4-thiadiazol-5- ylamino) acetyl) pyrrolidine-2-carbonitrile had been found to be strong anti-diabetic activity.
Cite this article:
Babaso V. Udugade, Shivaji P. Gawade. Synthesis and type- II anti-diabetic activity of Pyrrolidine-2-carbonitrile derived Ligands in SHR-STZ Animal model. Asian J. Research Chem. 2018; 11(1):159-165. doi: 10.5958/0974-4150.2018.00033.0
Cite(Electronic):
Babaso V. Udugade, Shivaji P. Gawade. Synthesis and type- II anti-diabetic activity of Pyrrolidine-2-carbonitrile derived Ligands in SHR-STZ Animal model. Asian J. Research Chem. 2018; 11(1):159-165. doi: 10.5958/0974-4150.2018.00033.0 Available on: https://ajrconline.org/AbstractView.aspx?PID=2018-11-1-33