ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): K.S. Nataraj, P. Sivalingachari, S. Sai Naveen, K. Alekhya

Email(s): kalakondan@yahoo.com

DOI: Not Available

Address: K.S. Nataraj*, P. Sivalingachari, S. Sai Naveen, K. Alekhya
Shri Vishnu College of Pharmacy, Bhimavaram, West Godavari District-534202 AP India
*Corresponding Author

Published In:   Volume - 6,      Issue - 9,     Year - 2013


ABSTRACT:
A novel reverse phase high performance liquid chromatographic method was developed and validated for the determination of Dasatinib monohydrate tablets. The method was found to be simple, precise and accurate. The method involved a mobile phase comprising of triethylamine buffer (pH 6.5 ± 0.05) and solvent mixture of methanol and Acetonitrile in 50: 50 v/v and a Cosmicsil BDS C18 (4.6 X 250, 5µ) column. The flow rate was maintained at 1.0 ml/min and the detection was done at 315 nm. The retention time was found to be 6.4 mins. The method was found to be linear in the concentration range of 10-30ppm. The analytical method was validated according to ICH guidelines (ICH Q2b). The correlation coefficient (r2) was found to be 0.9996, % recovery was 101.5-101% and %RSD for precision on replicate injection was 0.18 and intermediate precision for intraday precision at condition-I and II was 0.10, 0.11 and interday precision was 0.13% respectively. The precision study was precise, robust, and repeatable. LOD value was 2.83 and LOQ value was 9.41. The developed method was validated by performing validation parameters like linearity, accuracy, precision, specificity and robustness. The method was found to be reliable for the determination of Dasatinib monohydrate in pharmaceutical dosage forms.


Cite this article:
K.S. Nataraj, P. Sivalingachari, S. Sai Naveen, K. Alekhya. Method Development and Validation for the Estimation of Dasatinib Monohydrate Tablets by RP-HPLC. Asian J. Research Chem. 6(9): September 2013; Page 859-862.

Cite(Electronic):
K.S. Nataraj, P. Sivalingachari, S. Sai Naveen, K. Alekhya. Method Development and Validation for the Estimation of Dasatinib Monohydrate Tablets by RP-HPLC. Asian J. Research Chem. 6(9): September 2013; Page 859-862.   Available on: https://ajrconline.org/AbstractView.aspx?PID=2013-6-9-13


Recomonded Articles:

Author(s): Kateryna Taran, Ayaou Abderrahim, Vera Kravchenko, Olena Novosel, Svitlana Taran

DOI: 10.5958/0974-4150.2020.00034.6         Access: Open Access Read More

Author(s): Bhavna V. Mohite

DOI:         Access: Open Access Read More

Author(s): Bulusu Lakshmi Sushma1, Gutta Madhusudhan, Anireddy Jayashree

DOI: 10.5958/0974-4150.2017.00014.1         Access: Open Access Read More

Author(s): Y. Padmavathi, Akari Anjali, Nayaka Raghavendra Babu, P Ravi Kumar

DOI: 10.5958/0974-4150.2017.00064.5         Access: Open Access Read More

Author(s): Vatchavai Bhaskara Raju, Bonthu Mohan Gandhi, Kamatham Srinivas Sumanth, Kolli Srinivas, Tupakula N Venkata Lakshmi Neeraja

DOI: 10.5958/0974-4150.2017.00030.X         Access: Open Access Read More

Author(s): Alka Verma, Bhupesh Verma, Sunil Kumar Prajapati, Kishu Tripathi

DOI:         Access: Open Access Read More

Author(s): SS Chitlange, Kiran Bagri, DM Sakarkar

DOI:         Access: Open Access Read More

Author(s): Mukund Nagarnaik, Arun Sarjoshi, Ajay Bodkhe, Bhupendra Khanal, Mayuri Pise, Girish Pandya

DOI: 10.5958/0974-4150.2015.00102.9         Access: Open Access Read More

Author(s): Tentu Nageswara Rao, Muralidhar Reddy Avuthu, B. Venkata Reddy, SNVS Murthy

DOI: 10.5958/0974-4150.2016.00076.6         Access: Open Access Read More

Author(s): Sravani A

DOI: 10.5958/0974-4150.2018.00144.X         Access: Open Access Read More

Author(s): Banerjee S, Bonde CG, Merukar SS, Patil YR

DOI:         Access: Open Access Read More

Asian Journal of Research in Chemistry (AJRC) is an international, peer-reviewed journal devoted to pure and applied chemistry..... Read more >>>

RNI: Not Available                     
DOI: 10.5958/0974-4150 

Popular Articles


Recent Articles




Tags