ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Sk. Shaheda Sultana, P. Parveen, P.Usha, V. Vasu Naik, Rajesh Akki, M. Gayatri Ramya

Email(s): sshahedas@gmail.com

DOI: Not Available

Address: Sk. Shaheda Sultana1*, P. Parveen1, P.Usha1,V. Vasu Naik1, Rajesh Akki1, M. Gayatri Ramya2
1Hindu College of Pharmacy, Amaravathi Road Guntur-522002
2University College of Pharmaceutical Sciences, Acharya Nagarjuna University, Nagarjuna Nagar, Guntur-522 510
*Corresponding Author

Published In:   Volume - 7,      Issue - 1,     Year - 2014


ABSTRACT:
Evaluation of antimicrobial, antihelmentihic, analgesic, anti-inflammatory activity of Quinazolinones and Pyrazolinones. Antimicrobial activity is evaluated by the effectiveness of the compounds in this test is based on the size of the zone of inhibition. The zone of inhibition also depends on the diffusibility of synthesized compounds, the size of the inoculum, the type of medium and other factors. The concentrations of the synthesized compounds at the edge of zone of inhibition represent Minimal Inhibitory Concentration of synthesized compounds. Alternatively the synthesized compounds disc with different concentrations could be employed in the test. The MIC is the lowest concentration of antibiotic that exhibits the zone of inhibition on the assay plate. Antihelmenthic activity is evaluated by collecting earthworms and kept in to each petri plate containing drug solution at a time. The movement of the earth worms were observed. Time taken for the paralysis and death of the organism were noted. Analgesic activity is evaluated by administer of all the test compounds orally. Dip the tail tip of individual animals up to 5cm into hot water (maintained at 580c) , sixty minutes after oral administration of test compounds and 30 min after i.v. injection of morphine sulfate, and note the response time as the sudden withdrawal of the tail from the hot water.Anti inflammatory activity is evaluated by measuring the paw volume initially and at 1, 2, 3 and 4 hrs after histamine injection, using Plethysmograph. Our present research includes determining the effectiveness of synthesized products which is a mile stone of Indian industry for profitability and innovation.


Cite this article:
Sk. Shaheda Sultana, P. Parveen, P.Usha, V. Vasu Naik, Rajesh Akki, M. Gayatri Ramya. Pharmacological Evaluation of Synthesized Test Compounds of Quinazolinones and Pyrazolinones. Asian J. Research Chem 7(1): January 2014; Page 33-40.


Recomonded Articles:

Author(s): Arun Kumar, Vinita Gupta, Sanchita Singh, Y.K. Gupta

DOI: 10.5958/0974-4150.2017.00038.4         Access: Open Access Read More

Author(s): Vatchavai Bhaskara Raju, Bonthu Mohan Gandhi, Kamatham Srinivas Sumanth, Kolli Srinivas, Tupakula N Venkata Lakshmi Neeraja

DOI: 10.5958/0974-4150.2017.00030.X         Access: Open Access Read More

Author(s): Pankaj Baboo, Girendra Gautam, S.K. Gupta

DOI: 10.5958/0974-4150.2017.00039.6         Access: Open Access Read More

Author(s): Alka Verma, Bhupesh Verma, Sunil Kumar Prajapati, Kishu Tripathi

DOI:         Access: Open Access Read More

Author(s): Trapti Rastogi, Vijay Bhutda, Komal Moon, PB Aswar, SS Khadabadi

DOI:         Access: Open Access Read More

Author(s): SR Pattan, NS Dighe, SA Nirmal, AN Merekar, RB Laware, HV Shinde, DS Musmade

DOI:         Access: Open Access Read More

Author(s): B. A. Mukhitdinova, E. E. Ergozhin, A. I. Nikitina, K. Kh. Khakimbolatova

DOI: 10.5958/0974-4150.2017.00008.6         Access: Open Access Read More

Author(s): Anshul Sinha, A. K. Meena, P. Panda, Bhavana Srivastava, M. D. Gupta, M. M. Padhi

DOI:         Access: Open Access Read More

Author(s): J Vanitha, A Saravana Kumar, M Ganesh, VS Saravanan

DOI:         Access: Open Access Read More

Author(s): Hunasnalkar Shivraj G, Shaikh Gazi, Patil SM, Surwase Ulhas S

DOI:         Access: Open Access Read More

Author(s): Alok Singh Thakur, Parmanand Verma, Anish Chandy

DOI:         Access: Open Access Read More

Author(s): Sabale Prafulla, Potey Lata, Rahangdale Priya, Sabale Vidya

DOI: 10.5958/0974-4150.2019.00011.7         Access: Open Access Read More

Asian Journal of Research in Chemistry (AJRC) is an international, peer-reviewed journal devoted to pure and applied chemistry..... Read more >>>

RNI: Not Available                     
DOI: 10.5958/0974-4150 

Popular Articles


Recent Articles




Tags