ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Hunasnalkar Shivraj G, Shaikh Gazi, Patil SM, Surwase Ulhas S

Email(s): shivaraj2007@rediffmail.com

DOI: Not Available

Address: Hunasnalkar Shivraj G*, Shaikh Gazi, Patil SM and Surwase Ulhas S
ASPM’s, K. T. Patil College of Pharmacy, Osmanabad. (MS) 413501
*Corresponding Author

Published In:   Volume - 3,      Issue - 2,     Year - 2010


ABSTRACT:
Substituted benzothiazoles have received considerable attention during last two decades as they are endowed with variety of biological activities and have wide range of therapeutic properties. A Literature survey indicates that benzothiazole derivatives possess different pharmacological and biological activities; which of most potent activity are anti-inflammatory and anti-bacterial activity. The starting product is 6-substituted-1, 3-benzothiazol-2-amine was prepared from 4- substituted anilines and potassium thiocyanate in one step. Substituted Benzothiazolyl-2-amines were reacted with chloroacetyl chloride to yield 2-chloro acetyl amino-6-substitued benzothiazoles, which were reacted with 2-mercaptobenzothiazole and 2-hydrazinobenzthiazole gave 2-(1,3-benzothiazol-2-yl thio)-N-(6-substitued-1,3-benzothiazol-2-yl) acetamides and 2-[2-(1,3-benzothiazol-2-yl)hydrazino]-N-(6-methyl-1,3-benzothiazol-2-yl) acetamides respectively. The synthesized compounds were characterized by elemental analysis and spectral data.


Cite this article:
Hunasnalkar Shivraj G, Shaikh Gazi, Patil SM, Surwase Ulhas S. Synthesis and Biological Activities of Some Benzothiazole Derivatives. Asian J. Research Chem. 3(2): April- June 2010; Page 421-427.


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