ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Santosh Dighe, Nachiket Dighe, Pankaj S. Shinde, Ravi Lawre, Sunil Nirmal

Email(s): Email ID Not Available

DOI: Not Available

Address: Santosh Dighe*, Nachiket Dighe, Pankaj S. Shinde, Ravi Lawre and Sunil Nirmal
PRES’s Pravara Rural College of Pharmacy, Loni, MS, India-413736
*Corresponding Author

Published In:   Volume - 7,      Issue - 12,     Year - 2014


ABSTRACT:
The synthesis, structure and biological activity of Benzimidazole derivatives have long been the focus of research interests in the field of Medicinal Chemistry. A number of Benzimidazole derivatives have been reported to possess interesting biological activities such as antimicrobial activity, 5-HT4 Receptor Antagonists activity, anticancer activity. All synthesized compound were characterized by IR, H¬1-NMR and elemental Analysis. All the compounds were evaluated for Antibacterial activity at the concentration of 200 µcg/mL by using cup-plate agar diffusion method. The activity was carried out on different micro-organisms (E.coli, S. aureus, A.niger, C. albicans) measured in terms of zone of inhibition and compared the standard drug Levofloxacin and Amphotericin B for antimicrobial activity. All the newly synthesized derivatives were screened for Anti-inflammatory activity by an in-vitro method of Inhibition of protein denaturation using Ibuprofen as a standard. These compounds with the suitable molecular modification may prove as a drug of choice in the treatment of microbial infectious disease in future.


Cite this article:
Santosh Dighe, Nachiket Dighe, Pankaj S. Shinde, Ravi Lawre, Sunil Nirmal. Synthesis and Evaluation of Some New Benzimidazole Derivatives for their Anti-Microbial and Anti-Inflammatory Activities. Asian J. Research Chem. 7(12): December, 2014; Page 1023-1029.


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