ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Roopa H.R., Saravanan J., Mohan S., Rekha Parmesh

Email(s): roopad24@gmail.com

DOI: Not Available

Address: Roopa H.R.*, Saravanan J., Mohan S., Rekha Parmesh
Department of Pharmaceutical Chemistry, The PES College of Pharmacy, Hanumanthanagar, Bangalore.
*Corresponding Author

Published In:   Volume - 7,      Issue - 3,     Year - 2014


ABSTRACT:
The 2- amino (3-N-substituted carboxanilido)-4,5- di substituted thiophenes (JSR 1a-1h) was synthesized via a multicomponent condensation between sulphur, Ethyl methyl ketone and methoxy cyano acetanalide adapting Gewald reaction. Later it was diazotized to yield new compounds like thieno-1,2,3-triazin-4-ones (JSR2a-2h).The synthesized compounds were characterized by preliminary laboratory techniques like MP, TLC, IR and further confirmed by NMR and Mass spectra. The diazotized compounds (JSR2a-2h) were used for screening of in-vivo anti-inflammatory activity using Wistar rats. JSR2d, 2e and 2h showed the maximum reduction in paw volume of the rats and were found to be most significant compound and the compounds JSR-2a and 2c showed very mild anti-inflammatory activity and caused mild reduction in paw volume of the rats followed by JSR-2b, 2f and 2g.


Cite this article:
Roopa H.R., Saravanan J., Mohan S., Rekha Parmesh. Synthesis, Characterization and Anti-Inflammatory Activity of Some Novel Heterofused Thienotriazines. Asian J. Research Chem. 7(3): March 2014; Page 285-292.


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