A series of 6-aryl-5-cyano-2-thiouracil derivatives 2a-2e was synthesized by the reaction of ethyl cyanoacetate with thiourea and aldehydes , namely 4-chlorobenzaldehyde to give Compounds 6-(4-chlorophenyl)-4-oxo-2-thioxo-1, 2, 3, 4-tetrahydropyrimidine-5-carbonitrile , compound 1 were chlorinated to give the chloro compounds 2 that is 4-chloro-6-(4-chlorophenyl)-2-thioxo-1, 2dihydropyrimidine-5-carbonitrile. , then condensation of compound 2 via different reagents such as P-Bromoaniline, p-Nitrpaniline , hydrazine hydrate, 2,4-dinitroaniline, and anthranillic acid to give compounds 2a-2e respectively. All the synthesized compound was purified by successive recrystallization .the purity of compound was checked by performing TLC. For the TLC chloroform, methanol used as an mobile phase in the proportion of (9:1), and for visualization of the spot iodine vapor is used. All structures of the new compounds were elucidated by their spectral data such as IR, NMR. The antibacterial activity of all of these compounds was studied .The synthesized compounds are evaluated for anti-inflammatory activity.
Cite this article:
Sunita S. Patil, S. K. Mohite, C. S. Magdum. Synthesis and Evaluation of Anti-inflammatory Activity of some Pyrimidine Derivatives. Asian J. Research Chem. 8(8): August 2015; Page 507-510. doi: 10.5958/0974-4150.2015.00080.2