0974-4150 (Online)
0974-4169 (Print)

Author(s): Prafulla M Sabale, Dhiraj S Bhagwat, Karan Parwe


DOI: 10.5958/0974-4150.2018.00105.0   

Address: Prafulla M Sabale*, Dhiraj S Bhagwat, Karan Parwe
Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur-440033 M.S.
*Corresponding Author

Published In:   Volume - 11,      Issue - 3,     Year - 2018

The development of metal based drugs with promising pharmacological application and may offer unique therapeutic opportunities. The advances in inorganic chemistry provide better opportunities to use metal complexes as therapeutic agents as the mode of action of metal complexes on living organism is differing from non metals. The lipophilicity of the drug was found to increase through the formation of chelates by which drug action is significantly increased due to the effective permeability of the drug into the site of action. The fluoroquinolones are synthetic antibiotics, active against aerobic Gram (-ve) and Gram (+ve) microorganisms. Fluoroquinolones possess 3-carboxylate group and 4-keto group which are essential for formation of metal complex. Fe(III) complex of ciprofloxacin in presence of neutral bidentate ligand (N-N) donors 1,10-Phenanthroline had been synthesized. The structure of metal complex was confirmed by physiochemical parameters and spectroscopy techniques such as Quantitative UV, Mass Spectrometry, FT-IR spectroscopy and 1H NMR spectroscopy. Through UV studies the log e value and molar absorptivity (e) were compared indicating the attachment of only one mole of ciprofloxacin and 1,10-phenanthroline donor to the central Fe(III) metal ion. The stability study of complex was evaluated as per ICH guidelines and the complex was found to be a stable. Cipofloxacin complex was evaluated for its antibacterial activity against two different microorganisms (Escherichia coli and Staphylococcus aureus). Antibacterial activity of ciprofloxacin complex showed better activity as compared to ciprofloxacin alone.

Cite this article:
Prafulla M Sabale, Dhiraj S Bhagwat, Karan Parwe. Synthesis, Characterization and Biological Evaluation of Ciprofloxacin N-N Donor Metal Complex. Asian J. Research Chem. 2018; 11(3):588-592. doi: 10.5958/0974-4150.2018.00105.0

Recomonded Articles:

Author(s): Gullipilli Sandhya, R. Ravichandra Babu

DOI: 10.5958/0974-4150.2018.00115.3         Access: Open Access Read More

Author(s): Kateryna Taran, Ayaou Abderrahim, Vera Kravchenko, Olena Novosel, Svitlana Taran

DOI: 10.5958/0974-4150.2020.00034.6         Access: Closed Access Read More

Author(s): Virupakshi Prabhakar, Kondra Sudhakar Babu, L.K. Ravindranath, M. Sahanoor Basha, J. Latha

DOI: 10.5958/0974-4150.2017.00012.8         Access: Open Access Read More

Author(s): Ram C. Senwar, Krishna K. Rathore, Anita Mehta

DOI: 10.5958/0974-4150.2017.00022.0         Access: Open Access Read More

Author(s): Arun Kumar, Vinita Gupta, Sanchita Singh, Y.K. Gupta

DOI: 10.5958/0974-4150.2017.00038.4         Access: Open Access Read More

Author(s): Bulusu Lakshmi Sushma1, Gutta Madhusudhan, Anireddy Jayashree

DOI: 10.5958/0974-4150.2017.00014.1         Access: Open Access Read More

Author(s): Prathima Patil, S.P. Sethy, T. Sameena, K. Shailaja

DOI:         Access: Open Access Read More

Author(s): Y. Padmavathi, Akari Anjali, Nayaka Raghavendra Babu, P Ravi Kumar

DOI: 10.5958/0974-4150.2017.00064.5         Access: Open Access Read More

Author(s): Tauseef Shaikh, Atar Mujum , Khan Wasimuzzama, Rukhsana A Rub

DOI:         Access: Open Access Read More

Author(s): Vatchavai Bhaskara Raju, Bonthu Mohan Gandhi, Kamatham Srinivas Sumanth, Kolli Srinivas, Tupakula N Venkata Lakshmi Neeraja

DOI: 10.5958/0974-4150.2017.00030.X         Access: Open Access Read More

Author(s): SS Chitlange, Kiran Bagri, DM Sakarkar

DOI:         Access: Open Access Read More

Asian Journal of Research in Chemistry (AJRC) is an international, peer-reviewed journal devoted to pure and applied chemistry..... Read more >>>

RNI: Not Available                     
DOI: 10.5958/0974-4150 

Popular Articles

Recent Articles