Author(s):
Kishore Gokavarapu, Rahul Uttamrao Devkar, Sarita Gokavarapu, Shiva Rama Krishna Samala, Durga Prasad Rao
Email(s):
g.kishore@live.com
DOI:
10.5958/0974-4150.2019.00012.9 
Address:
Kishore Gokavarapu1*, Rahul Uttamrao Devkar1, Sarita Gokavarapu3, Shiva Rama Krishna Samala2, Durga Prasad Rao3
1Production Department-Helios Lifesciences Limited, 79 and 100, Industrial Growth Center, Malanpur,
District: Bhind, MP–477117
2 Research and Development Department–Helios Lifesciences Limited, 79 & 100, Industrial Growth Center, Malanpur, District: Bhind, MP-477117
3QC and ADL Department–Helios Lifesciences Limited, 79 & 100, Industrial Growth Center, Malanpur, District: Bhind, MP-477117
*Corresponding Author
Published In:
Volume - 12,
Issue - 2,
Year - 2019
ABSTRACT:
The present paper describes the CAL-B (Enzymatic) desmmetrization of Prochiral Dimethyl 3-Isobutylpentanedioate was performed to prepare optically active (S)-3-(2-methoxy2-oxoethyl)-5-methylhexanoic acid. Based on this reaction, the synthesis of (S)-(+)-3-aminomethyl-5-methylhexanoic acid (S-Pregabalin) was achieved with a 70-75% overall yield.
Cite this article:
Kishore Gokavarapu, Rahul Uttamrao Devkar, Sarita Gokavarapu, Shiva Rama Krishna Samala, Durga Prasad Rao. An Efficient and Novel Synthesis of Pregabalin with Enantioselective Enzymatic Hydrolysis using CAL-B Enzyme. Asian J. Research Chem. 2019; 12(2):55-57. doi: 10.5958/0974-4150.2019.00012.9
Cite(Electronic):
Kishore Gokavarapu, Rahul Uttamrao Devkar, Sarita Gokavarapu, Shiva Rama Krishna Samala, Durga Prasad Rao. An Efficient and Novel Synthesis of Pregabalin with Enantioselective Enzymatic Hydrolysis using CAL-B Enzyme. Asian J. Research Chem. 2019; 12(2):55-57. doi: 10.5958/0974-4150.2019.00012.9 Available on: https://ajrconline.org/AbstractView.aspx?PID=2019-12-2-2