ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Afnan E. Abd-Almonuim, Shaimaa M. Mohammed, Ihab I. Al-Khalifa

Email(s): afnan.abdalmonuim@gmail.com

DOI: 10.5958/0974-4150.2020.00006.1   

Address: Afnan E. Abd-Almonuim1*, Shaimaa M. Mohammed2 , Ihab I. Al-Khalifa1
1Al-Rasheed University College, Baghdad, Iraq,
2Al-Mustaqbal University Collage, Babylon, Iraq
*Corresponding Author

Published In:   Volume - 13,      Issue - 1,     Year - 2020


ABSTRACT:
The recent work involves the preparation and characterization of 3-(4-hydroxy-4H-benzo [4,5] thiazolo [3,2-a] pyrimidin-4-yl)-2H-chromen-2-one derivative in dioxin-ethanol medium. The enamine (E)-1,1-dimethyl-3-((2-oxo-2H-chromen-3-yl) methylene) urea was treated in dioxin solvent with ethanolic solution of 2-aminobenzothiazole to produce named 3-(4-hydroxy-4H-benzo[4,5]thiazolo[3,2-a]pyrimidin-4-yl)-2H-chromen-2-one compound [L]. The prepared derivatives, enamine [A] and [L] were characterized through (C.H.N.S) analyses, FT-IR, 1HNMR as well Mass spectral. The scavenging ability from different ethanolic solution ranging from (100-1000 ug/ml) of the new compound against stable DPPH radical (DPPH•) was done and the results show that the coumarin derivative of this compound exhibited high antioxidant activates with scavenging activity reaching 80 % at concentration 1000 µg/mL , compared to vitamin c as standard antioxidant reaching 92% DPPH radical scavenging activity at the same concentration.


Cite this article:
Afnan E. Abd-Almonuim, Shaimaa M. Mohammed , Ihab I. Al-Khalifa. Preparation, Characterization and Antioxidant Determination of Coumarin Substituted Heterocyclic Compound. Asian J. Research Chem. 2020; 13(1): 23-27. doi: 10.5958/0974-4150.2020.00006.1


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