ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Rushikesh K. Sonawane, Shrinivas K. Mohite

Email(s): rushikesh.sonawane509@gmail.com

DOI: 10.52711/0974-4150.2021.00038   

Address: Rushikesh K. Sonawane*, Shrinivas K. Mohite
Department of Pharmaceutical Chemistry, Rajarambapu College of Pharmacy, Kasegaon, Maharashtra, India- 415404.
*Corresponding Author

Published In:   Volume - 14,      Issue - 3,     Year - 2021


ABSTRACT:
There has been considerable interest in the development of novel anticonvulsant compounds, , analgesic, anti-inflammatory, antimicrobial, antimycobacterial, antitumour, and antitubercular activities. 1,3,4-thiadiazole constitute Significant class of compounds for new drugs development. They Have an interesting pharmacophore displaying a wide range of pharmacological activity. The 1,3,4-thiadiazole compound is an interesting heterocycle. A group that was used to synthesise a variety of useful bioactive compounds. The stability of the thiadiazole nucleus has inspired the medicinal chemist to perform various structural variations in the ring. Marketed drugs such as acetazolamide and methazolamide have shown their therapeutic potential Therefore, many researchers have identified these compounds as target structures and evaluated their biological activities. This review highlights the different pharmacological activities associated with the 1,3,4-thiadiazole ring system.


Cite this article:
Rushikesh K. Sonawane, Shrinivas K. Mohite. Heterocyclic Bridgehead Nitrogen Atom System: Review on [1,2,4] Triazolo[3,4-b] [1,3,4] thiadiazole and Its Pharmacological Screening. Asian Journal of Research in Chemistry. 2021; 14(3):217-0. doi: 10.52711/0974-4150.2021.00038

Cite(Electronic):
Rushikesh K. Sonawane, Shrinivas K. Mohite. Heterocyclic Bridgehead Nitrogen Atom System: Review on [1,2,4] Triazolo[3,4-b] [1,3,4] thiadiazole and Its Pharmacological Screening. Asian Journal of Research in Chemistry. 2021; 14(3):217-0. doi: 10.52711/0974-4150.2021.00038   Available on: https://ajrconline.org/AbstractView.aspx?PID=2021-14-3-10


REFERENCES: -
1.    Halit M, Hasan Y, Hanan A S, New 1,3,4-thiadiazoles based on thiophene-2- carboxylic acid synthesis, characterization and antimicrobial activities. Journal of Molecular Structure. 2019; 1203: 1-30.
2.    Haider S, Alam MS, Hamid H, 1, 3, 4-thiadiazoles a potent multi targeted pharmacological scaffold. European Journal of Medicinal Chemistry. 2015; 92: 156- 77.
3.    Joule A and Mills K, Heterocylic Chemistry, Blackwell Publisher, Germany, 4th Edition, 1-2.
4.    Bansal RK, Heterocylic chemistry, New Age International Publishers, 4th edition, 1-2.
5.    Mathew V, Keshavayya  J, Vaidya VP, Giles D. Studies on synthesis and pharmacological activities of 3,6-disubstituted1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles and their dihydro analogues. European Journal of Medicinal Chemistry. 2007; 42: 823-40.
6.    Amir M, Kumar H, Javed SA. Condensed bridgehead nitrogen heterocyclic system: synthesis and pharmacological activities of 1,2,4-triazolo-[3,4-b]-1,3,4-thiadiazole derivatives of ibuprofen and biphenyl-4-yloxy acetic acid. European Journal of Medicinal Chemistry. 2008; 43: 2056-66.
7.    Yang X, Wen Q, Zhao T, Sun J, Li X, Xing M, et al. Synthesis, biological evaluation, and molecular docking studies of cinnamic acyl 1,3,4-thiadiazole amide derivatives as novel antitubulin agents. Bioorganic Med Chem. 2012; 20: 1181–7.
8.    Mathew V, Keshavayya J , Vaidya VP, Heterocyclic system containing bridgehead nitrogen atom: synthesis and pharmacological activities of some substituted 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles. European Journal of Medicinal Chemistry. 2006; 41: 1048-1058.

Recomonded Articles:

Author(s): Gullipilli Sandhya, R. Ravichandra Babu

DOI: 10.5958/0974-4150.2018.00115.3         Access: Open Access Read More

Author(s): Kateryna Taran, Ayaou Abderrahim, Vera Kravchenko, Olena Novosel, Svitlana Taran

DOI: 10.5958/0974-4150.2020.00034.6         Access: Open Access Read More

Author(s): Prathima Patil, S.P. Sethy, T. Sameena, K. Shailaja

DOI:         Access: Open Access Read More

Author(s): Ram C. Senwar, Krishna K. Rathore, Anita Mehta

DOI: 10.5958/0974-4150.2017.00022.0         Access: Open Access Read More

Author(s): Virupakshi Prabhakar, Kondra Sudhakar Babu, L.K. Ravindranath, M. Sahanoor Basha, J. Latha

DOI: 10.5958/0974-4150.2017.00012.8         Access: Open Access Read More

Author(s): Arun Kumar, Vinita Gupta, Sanchita Singh, Y.K. Gupta

DOI: 10.5958/0974-4150.2017.00038.4         Access: Open Access Read More

Author(s): Bulusu Lakshmi Sushma1, Gutta Madhusudhan, Anireddy Jayashree

DOI: 10.5958/0974-4150.2017.00014.1         Access: Open Access Read More

Author(s): Y. Padmavathi, Akari Anjali, Nayaka Raghavendra Babu, P Ravi Kumar

DOI: 10.5958/0974-4150.2017.00064.5         Access: Open Access Read More

Author(s): Tauseef Shaikh, Atar Mujum , Khan Wasimuzzama, Rukhsana A Rub

DOI:         Access: Open Access Read More

Author(s): Vatchavai Bhaskara Raju, Bonthu Mohan Gandhi, Kamatham Srinivas Sumanth, Kolli Srinivas, Tupakula N Venkata Lakshmi Neeraja

DOI: 10.5958/0974-4150.2017.00030.X         Access: Open Access Read More

Author(s): SS Chitlange, Kiran Bagri, DM Sakarkar

DOI:         Access: Open Access Read More

Asian Journal of Research in Chemistry (AJRC) is an international, peer-reviewed journal devoted to pure and applied chemistry..... Read more >>>

RNI: Not Available                     
DOI: 10.5958/0974-4150 

Popular Articles


Recent Articles




Tags