ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): RB Kakde, AG Barsagade, NK Chaudhary, DL Kale

Email(s): drkakde@yahoo.com

DOI: Not Available

Address: RB Kakde*, AG Barsagade, NK Chaudhary and DL Kale
Department of Pharmaceutical Sciences, RTM Nagpur University, Amravati Road, Nagpur – 440 033, (MS) INDIA.
* Corresponding Author

Published In:   Volume - 2,      Issue - 1,     Year - 2009


ABSTRACT:
A simple, precise and accurate spectrophotometric method has been developed for the determination of ticlopidine HCl in bulk and pharmaceutical dosage form. Standard stock solution was prepared in methanol and further dilutions were carried out with distilled water. The ?max of ticlopidine HCl was found to be 213.60. The A (1%, 1cm) value of ticlopidine HCl was found to be 405.204 ± 2.243. Calibration graph was linear over the range of 1-50µg/ml. The correlation coefficient (r) was found to be 0.999. The limit of detection (LOD) and limit of quantitation (LOQ) was found to be 0.6344 µg/ml and 1.9224 µ g/ml respectively for ticlopidine HCl. The result of estimation in marketed tablet formulation was found to be 100.72 ± 0.84 %. The proposed method was applied successfully for the determination of ticlopidine HCl in tablets with average recovery of 99.93 ± 0.27 %. The method was then validated statistically as per ICH guidelines, which yielded good results concerning range, linearity, precision, accuracy, specificity, robustness and ruggedness.


Cite this article:
RB Kakde, AG Barsagade, NK Chaudhary, DL Kale. Spectrophotometric Method for Estimation of Ticlopidine HCl in Bulk and Dosage Form. Asian J. Research Chem. 1(2): Oct.-Dec. 2008; Page 73-75.


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