ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Patil Shamkant S, Dhabale Pandurang N, Kuchekar Bhanudas S

Email(s): Shamkantpatil7@rediffamil.com

DOI: Not Available

Address: Patil Shamkant S*1, Dhabale Pandurang N1 and Kuchekar Bhanudas S2
1Govt. College of Pharmacy, Vidyanagar, Karad-415124, Maharashtra, India
2Maharashtra Institute of Pharmacy, Pune, Maharashtra, India
*Corresponding Author

Published In:   Volume - 2,      Issue - 2,     Year - 2009


ABSTRACT:
Three simple, precise and economical UV methods have been developed for the estimation of Esomeprazole in bulk and pharmaceutical formulations. Esomeprazole has the absorbance maxima at 303nm (Method A), and in the first order derivative spectra, showed zero crossing at 303nm, with a sharp peak at 292nm when n=1 (Method B), Method C applied was Area Under Curve (AUC) for analysis of Esomeprazole in the wavelength range of 294-310nm. Drug followed the Beer’s Lamberts range of 5-40 µg/ml for the Method A, B C. Results of analysis were validated statistically and by recovery studies and were found to be satisfactory.


Cite this article:
Patil Shamkant S, Dhabale Pandurang N, Kuchekar Bhanudas S. Development and Statistical Validation of Spectrophotometric Method for Estimation of Esomeprazole in Tablet Dosage Form. Asian J. Research Chem. 2(2): April.-June, 2009 page 154-156


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