Indrani Bhattacharyya, Subhra Prakash Bhattacharyya, Subrata Sen, Tapas Ku Laha
Indrani Bhattacharyya1*, Subhra Prakash Bhattacharyya1, Subrata Sen2 and Tapas Ku Laha2
1Department of Pharmaceutical Chemistry, Dr B.C Roy College of Pharmacy and Allied Health Sciences, Meghnath Shah Sarani, Bidhan Nagar, Durgapur-6, West Bengal, India
2College of Pharmaceutical Sciences, Mohuda
Volume - 2,
Issue - 3,
Year - 2009
A rapid and sensitive reverse phase HPLC method is depicted for the qualitative and quantitative assay of Etoricoxib in pharmaceutical dosage forms. Etoricoxib was chromatographed on a reverse phase C18 column with a mobile phase consisting of methanol: phosphate buffer (pH-7.8) in the ratio of 90:10 v/v.The mobile phase was pumped at a flow rate of 1ml/min. Mirtazapine was used as an internal standard and the eluents were monitored at 235 nm. The retention time of the drug was 3.428 min.With this method, linearity is observed between area under curve (AUC, expressed in mV.min) and concentration of Etoricoxib in the injected solution, in the range of 10-200 µg/ml.The method was found to be applicable for analysis of drug in tablets. The results of the analysis were validated statistically.
Cite this article:
Indrani Bhattacharyya, Subhra Prakash Bhattacharyya, Subrata Sen, Tapas Ku Laha. Reverse Phase High Performance Liquid Chromatographic Method for the Analysis of Etoricoxib in Pharmaceutical Dosage Form. Asian J. Research Chem. 2(3): July-Sept., 2009, page 297-299.