Jacob Jincy, Dey Tathagata, Ghate Manjunath, Baby Shaji
Jacob Jincy1, Dey Tathagata1*, Ghate Manjunath2 and Baby Shaji3
1East Point College of Pharmacy, Bidarahalli, Virgonagar Post, Bangalore- 560049
2Krupanidhi College of Pharmacy, Chikkabelandur, Carmelaram Post, Varthur Hobli, Bangalore-560035
3Badar Al Samaa Hospital, P.O Box-516, P C-321, Barka, Sultanate of Oman
Volume - 3,
Issue - 1,
Year - 2010
A series of eight coumarino benzimidazoles have been synthesized from 4-fluro-3-nitrobenzoic acid with the help of a supporting polymer PEG5000 and with suitable reagents. These compounds have then been subjected to preliminary anti-inflammatory screening using formaline induce rat paw oedema model. All the synthesized compounds have activity comparable to indomethacin (20 mg/kg) by intraperitonial route.
Cite this article:
Jacob Jincy, Dey Tathagata, Ghate Manjunath, Baby Shaji. Synthesis of Some Novel Coumarino Benzimidazoles Derivatives for Anti-Inflammatory Screening. Asian J. Research Chem. 3(1): Jan.-Mar. 2010; Page 116-120.