HG Akkamma, BS Vikram, T Srinivas Rao, D Baggiya Selvi
HG Akkamma*, BS Vikram, T Srinivas Rao and D Baggiya Selvi
Karnataka College of Pharmacy, # 33\2, Thirumenahalli, Hegde Nagar Main Road, Yelahanka Hobli, Jakkur Post, Bangalore-560064
Volume - 3,
Issue - 2,
Year - 2010
Nimesulide (Biphenyl Ether) derivatives were synthesized by four steps, Step-1- Ulmaan ether synthesis, Step-2- Reduction of NO2, Step-3- Condensation reaction, Step-4- Nitration and evaluated for their anti-inflammatory and analgesic activities.
The compounds have been characterized on the basis of preliminary methods, spectral data and tested for anti- inflammatory activity and compared with standard drug as per the standard drug rat hind paw edema method by using Plethesimograph and analgesic activity by Eddies-hotplate method. Among the derivatives prepared, few showed the moderate activity and few showed decreased activity.
Cite this article:
HG Akkamma, BS Vikram, T Srinivas Rao, D Baggiya Selvi. Synthesis and Screening of Biphenyl ether derivatives for their Anti-inflammatory and Analgesic activity. Asian J. Research Chem. 3(2): April- June 2010; Page 308-311.