ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): HG Akkamma, BS Vikram, T Srinivas Rao, D Baggiya Selvi

Email(s): mankar2007@rediffmail.com

DOI: Not Available

Address: HG Akkamma*, BS Vikram, T Srinivas Rao and D Baggiya Selvi
Karnataka College of Pharmacy, # 33\2, Thirumenahalli, Hegde Nagar Main Road, Yelahanka Hobli, Jakkur Post, Bangalore-560064
*Corresponding Author

Published In:   Volume - 3,      Issue - 2,     Year - 2010


ABSTRACT:
Nimesulide (Biphenyl Ether) derivatives were synthesized by four steps, Step-1- Ulmaan ether synthesis, Step-2- Reduction of NO2, Step-3- Condensation reaction, Step-4- Nitration and evaluated for their anti-inflammatory and analgesic activities. The compounds have been characterized on the basis of preliminary methods, spectral data and tested for anti- inflammatory activity and compared with standard drug as per the standard drug rat hind paw edema method by using Plethesimograph and analgesic activity by Eddies-hotplate method. Among the derivatives prepared, few showed the moderate activity and few showed decreased activity.


Cite this article:
HG Akkamma, BS Vikram, T Srinivas Rao, D Baggiya Selvi. Synthesis and Screening of Biphenyl ether derivatives for their Anti-inflammatory and Analgesic activity. Asian J. Research Chem. 3(2): April- June 2010; Page 308-311.


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