MonagoC.C., Amachree I., Joshua P.E.
MonagoC.C.,1* Amachree I. 1 and Joshua P.E. 2
1Department of Biochemistry, University of Port Harcourt, Choba, Rivers State, Nigeria
2Department of Biochemistry, University of Nigeria, Nsukka, Enugu State, Nigeria
Volume - 3,
Issue - 3,
Year - 2010
Background : Cardiovascular diseases with high levels of creatine kinase have been reported in diabetics as major killer, globally. Can single effect of diabinese(DB)- antidiabetic drug and combined effects of DB and nicotinic acid (NA)- a vitamin and an antilipidemic drug be used to manage diabetes and this associated cardiovascular disease?
Method : Dithizone induced-diabetic rabbits grouped into A, B, C, D and E were treated for 72 hrs with 10mg DB, 10mg DB/150mg NA, 10mgDB/200mg NA, 10mg DB/250mg NA, and 5ml of Distil water respectively.
Result Dithizone increased the blood glucose, urea, creatinine and creatine kinase levels. Combined therapy of DB/NA did not affect the urea level but significantly (p<0.05) reduced the levels of glucose, creatinine and creatine kinase than in single therapy.
Conclusion.Combination of diabinese and nicotinic acid could be used to reduce the high levels of glucose, creatinine and creatine kinase associated with diabetes and cardiovascular disease.
Cite this article:
MonagoC.C., Amachree I., Joshua P.E. . Diabinese and Nicotinic acid Combination Reduced Cardiovascular Indices in Experimental DiabetesAsian J. Research Chem. 3(3): July- Sept. 2010; Page 785-790.