Curcumin is a phytopolyphenolic component and active principle of turmeric. Curcumin inhibits the formation of reactive oxygen species formation and is anti-inflammatory. It inhibits the various enzymes involved in inflammation. Curcumin is also known to be an antimicrobial, antioxidant, anti-inflammatory to inhibition of angiogenesis, chemopreventive and anticancer agent. However in spite of all its therapeutic properties in vitro, it fails to be an active drug in vivo due to its poor bioavailability, rapid metabolism and an overall poor pharmacodynamic and pharmacokinetic activities. Studies are uncertain whether these compounds act independently, additively or synergistically with curcumin to exhibit the above mentioned properties. Inflammation of either upper urinary tract or lower urinary tract caused by invasion of uropathogens is recognised as Urinary Tract Infection (UTI), of which infection of the lower urinary tract is the most common and is characterised by asymptomatic bacteraemia, pelvic pain, frequent urination, urge to urinate, etc. Women are more susceptible to UTI than men owing to the shorter length of urethra. Recurrent UTI is seen to be a characteristic of infection by MDR strains of uropathogens, developed due to chronic illness, prolonged and frequent hospitalisation, previous history of endoscopic surgery and diabetes mellitus type 2. The present study is aimed at studying the effect of protein extracts of curcumin from the plant sample yielding the maximum inhibition against the uropathogen isolated from urine sample obtained from a diabetic patient suffering from UTI. The active principle of turmeric, curcumin and curcumin free turmeric extract were tested in vitro for its antibacterial activities against the bacterial isolate and were found to be nil. However, the protein extracts of the crude curcumin showed a positive response in inhibiting the isolate.
Cite this article:
T. Sharanya Nair, Meghana R, Shlini P.Antimicrobial Activity of the protein fraction obtained in the extraction of Curcumin. Asian J. Research Chem. 2019; 12(4):199-202. doi: 10.5958/0974-4150.2019.00037.3 9