ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): T. Sharanya Nair, Meghana R, Shlini P

Email(s): shlinip1@gmail.com

DOI: 10.5958/0974-4150.2019.00037.3 9   

Address: T. Sharanya Nair, Meghana R, Shlini P*
Department of Chemistry (PG Biochemistry). Mount Carmel College, Autonomous. #58. Palace Road. Bangalore - 560052. Karnataka. India.
*Corresponding Author

Published In:   Volume - 12,      Issue - 4,     Year - 2019


ABSTRACT:
Curcumin is a phytopolyphenolic component and active principle of turmeric. Curcumin inhibits the formation of reactive oxygen species formation and is anti-inflammatory. It inhibits the various enzymes involved in inflammation. Curcumin is also known to be an antimicrobial, antioxidant, anti-inflammatory to inhibition of angiogenesis, chemopreventive and anticancer agent. However in spite of all its therapeutic properties in vitro, it fails to be an active drug in vivo due to its poor bioavailability, rapid metabolism and an overall poor pharmacodynamic and pharmacokinetic activities. Studies are uncertain whether these compounds act independently, additively or synergistically with curcumin to exhibit the above mentioned properties. Inflammation of either upper urinary tract or lower urinary tract caused by invasion of uropathogens is recognised as Urinary Tract Infection (UTI), of which infection of the lower urinary tract is the most common and is characterised by asymptomatic bacteraemia, pelvic pain, frequent urination, urge to urinate, etc. Women are more susceptible to UTI than men owing to the shorter length of urethra. Recurrent UTI is seen to be a characteristic of infection by MDR strains of uropathogens, developed due to chronic illness, prolonged and frequent hospitalisation, previous history of endoscopic surgery and diabetes mellitus type 2. The present study is aimed at studying the effect of protein extracts of curcumin from the plant sample yielding the maximum inhibition against the uropathogen isolated from urine sample obtained from a diabetic patient suffering from UTI. The active principle of turmeric, curcumin and curcumin free turmeric extract were tested in vitro for its antibacterial activities against the bacterial isolate and were found to be nil. However, the protein extracts of the crude curcumin showed a positive response in inhibiting the isolate.


Cite this article:
T. Sharanya Nair, Meghana R, Shlini P.Antimicrobial Activity of the protein fraction obtained in the extraction of Curcumin. Asian J. Research Chem. 2019; 12(4):199-202. doi: 10.5958/0974-4150.2019.00037.3 9


Recomonded Articles:

Author(s): Gullipilli Sandhya, R. Ravichandra Babu

DOI: 10.5958/0974-4150.2018.00115.3         Access: Open Access Read More

Author(s): Kateryna Taran, Ayaou Abderrahim, Vera Kravchenko, Olena Novosel, Svitlana Taran

DOI: 10.5958/0974-4150.2020.00034.6         Access: Closed Access Read More

Author(s): Syed Tasleem Hussain, Gul Abad Khan, Muhammad Shabeer

DOI:         Access: Open Access Read More

Author(s): Bulusu Lakshmi Sushma1, Gutta Madhusudhan, Anireddy Jayashree

DOI: 10.5958/0974-4150.2017.00014.1         Access: Open Access Read More

Author(s): Prathima Patil, S.P. Sethy, T. Sameena, K. Shailaja

DOI:         Access: Open Access Read More

Author(s): Y. Padmavathi, Akari Anjali, Nayaka Raghavendra Babu, P Ravi Kumar

DOI: 10.5958/0974-4150.2017.00064.5         Access: Open Access Read More

Author(s): Tauseef Shaikh, Atar Mujum , Khan Wasimuzzama, Rukhsana A Rub

DOI:         Access: Open Access Read More

Author(s): Vatchavai Bhaskara Raju, Bonthu Mohan Gandhi, Kamatham Srinivas Sumanth, Kolli Srinivas, Tupakula N Venkata Lakshmi Neeraja

DOI: 10.5958/0974-4150.2017.00030.X         Access: Open Access Read More

Author(s): Alka Verma, Bhupesh Verma, Sunil Kumar Prajapati, Kishu Tripathi

DOI:         Access: Open Access Read More

Author(s): Pankaj Baboo, Girendra Gautam, S.K. Gupta

DOI: 10.5958/0974-4150.2017.00039.6         Access: Open Access Read More

Author(s): Virupakshi Prabhakar, Kondra Sudhakar Babu, L.K. Ravindranath, J. Latha, B.Venkateswarlu

DOI: 10.5958/0974-4150.2017.00011.6         Access: Open Access Read More

Asian Journal of Research in Chemistry (AJRC) is an international, peer-reviewed journal devoted to pure and applied chemistry..... Read more >>>

RNI: Not Available                     
DOI: 10.5958/0974-4150 

Popular Articles


Recent Articles




Tags