ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Bhavini N. Patel, Bhanubhai N. Suhagia, Chaganbhai N. Patel

Email(s): bhavi_pharma22783@yahoo.co.in

DOI: Not Available

Address: Bhavini N. Patel1*, Bhanubhai N. Suhagia2and Chaganbhai N. Patel1
1Department of Pharm. Chem., Shri Sarvajanik Pharmacy College, Mehsana-384001
2Department of Pharm. Chem., L.M. College of Pharmacy, Navrangpura, Ahmedabad-380009
*Corresponding Author

Published In:   Volume - 3,      Issue - 4,     Year - 2010


ABSTRACT:
A simple, precise, rapid and accurate reverse phase HPLC method was developed for the estimation of emtricitabine in capsule dosage form. A Phenomenex (Torrance, CA) C8 column, 250× 4.6 mm id, column, at ambient temperature with mobile phase consisting of 0.03M potassium dihydrogen phosphate (pH 4.86±0.02): Acetonitrile: Methanol (40:20:40 v/v/v) was used. The flow rate was 1 mL/min and the effluent was monitored at 260 nm. The retention time was 2.95 min. The detector response was linear in the concentration of 8-60 µg/mL. The respective linear regression equation being Y=27675x+41556. The limit of detection and limit of quantification was 0.06 and 0.20µg/mL respectively. The percentage assay of emtricitabine was 100.53%. The method was validated by determining its accuracy, precision and system suitability. The results of the study showed that the proposed RP-HPLC method is simple, rapid, precise and accurate, which is useful for the routine determination of emtricitabine in bulk drug and in its pharmaceutical dosage form.


Cite this article:
Bhavini N. Patel, Bhanubhai N. Suhagia, Chaganbhai N. Patel. Development and Validation of HPLC Method for the Estimation of Emtricitabine in Capsule Dosage Form. Asian J. Research Chem. 3(4): Oct. - Dec. 2010; Page 869-871.


Recomonded Articles:

Author(s): Y. Padmavathi, Akari Anjali, Nayaka Raghavendra Babu, P Ravi Kumar

DOI: 10.5958/0974-4150.2017.00064.5         Access: Open Access Read More

Author(s): Vatchavai Bhaskara Raju, Bonthu Mohan Gandhi, Kamatham Srinivas Sumanth, Kolli Srinivas, Tupakula N Venkata Lakshmi Neeraja

DOI: 10.5958/0974-4150.2017.00030.X         Access: Open Access Read More

Author(s): Alka Verma, Bhupesh Verma, Sunil Kumar Prajapati, Kishu Tripathi

DOI:         Access: Open Access Read More

Author(s): SS Chitlange, Kiran Bagri, DM Sakarkar

DOI:         Access: Open Access Read More

Author(s): Banerjee S, Bonde CG, Merukar SS, Patil YR

DOI:         Access: Open Access Read More

Author(s): B. Balaswami, P. Venkata Ramana, B. Subba Rao, P. Sanjeeva

DOI: 10.5958/0974-4150.2018.00023.8         Access: Open Access Read More

Author(s): Ismail, R Rajavel, M Ganesh, M Jagadeeswaran, K Srinivasan, J Valarmathi, T Sivakumar

DOI:         Access: Open Access Read More

Author(s): PA Jadhav, CS Raut, JP Bidada, BB Buwa, PN Dhabale, SC Dhawale

DOI:         Access: Open Access Read More

Author(s): Manorama B. Motegaonkar, S. D. Salunke

DOI: 10.5958/0974-4150.2017.00025.6         Access: Open Access Read More

Author(s): VB Kshirsagar, UA Deokate, VB Bharkad, SS Khadabadi

DOI:         Access: Open Access Read More

Author(s): S. Ganapathy, G.V.H. Raju, D.G. Sankar, Pettla Y. Naidu

DOI:         Access: Open Access Read More

Asian Journal of Research in Chemistry (AJRC) is an international, peer-reviewed journal devoted to pure and applied chemistry..... Read more >>>

RNI: Not Available                     
DOI: 10.5958/0974-4150 

Popular Articles


Recent Articles




Tags