Asian Journal of Research in Chemistry

ISSN

0974-4150 (Online)
0974-4169 (Print)


Submit Article

Role of Bio-Metal Zn (II) in Anticancer Behaviour of Tamoxifen

Author(s): Jyotsna Shukla, Brijesh Singh, K.S. Pitre

Email(s): vision_bsin@yahoo.com

DOI: Not Available

Address: Jyotsna Shukla1, Brijesh Singh1 and K.S. Pitre2
1AISECT Institute of Science and Technology Bhopal (M.P.) India
2Dr. Hari Singh Gour University Sagar 470 003 (M.P.) India
*Corresponding Author

Published In:   Volume - 3,      Issue - 4,     Year - 2010

 View HTML        View PDF

ABSTRACT:
Physicochemical, microbial and Pharmacological studies on Zn (II) - Tamoxifen complex have been done in solid and aqueous phase. On the basis of elemental analysis, polarographic studies, amperometric titrations and IR spectral studies the probable formula of the complex has been worked out to be 1:1 Zn (II) - Tamoxifen. The metal ligand interaction has been studied using polarographic method at 25+1°C and at ionic strength of µ= 1.0 [KCl]. Microbial studies on the complex were done against various pathogenic bacteria viz. Pseudomonas mangiferae, Staphylococus aureus, Salmonella typhi and Vibreo colarae and fungi i.e. Trichothesium and Chrysosporium sp. using Raper's method. The results indicated increased toxicity of the metal drug complex against bacteria and fungi, understudy. Mouse Sarcoma Cell line - 180 and Balb/C mice were used for the anticancer screening of solid complex in-vitro and in-vivo respectively the result of pharmacological studies with the Metal: Drug complex revealed that the complex more potent as compared to the pure drug regards to its anticancer activity. As such tamoxifen complex may be recommended to the therapeutic experts for its possible use as more potent anticancer drug.


Keywords:

Cite this article:
Jyotsna Shukla, Brijesh Singh, K.S. Pitre. Role of Bio-Metal Zn (II) in Anticancer Behaviour of Tamoxifen. Asian J. Research Chem. 3(4): Oct. - Dec. 2010; Page 981-985.

Cite(Electronic):
Jyotsna Shukla, Brijesh Singh, K.S. Pitre. Role of Bio-Metal Zn (II) in Anticancer Behaviour of Tamoxifen. Asian J. Research Chem. 3(4): Oct. - Dec. 2010; Page 981-985.   Available on: https://ajrconline.org/AbstractView.aspx?PID=2010-3-4-39


Recomonded Articles:

Structural and Biological Activity Studies on Metal Complexes Containing Thiosemicarbzone and Isatin Based Schiff Base: A Review

Author(s): Saddam Hossain, C. M. Zakaria, Kudrat-E-Zahan

DOI: 10.5958/0974-4150.2017.00002.5         Access: Open Access Read More

Latest Strategy of Medicinal Chemistry Implements In-silico After In-Vivo and In-Vitro

Author(s): Ravi N. Patel, Urviben Y. Patel, Kiran M. Patel, Jimit S. Patel, Ankit D. Patel, Dhrubo Jyoti Sen

DOI:         Access: Open Access Read More

Synthesis of Some Chalcone and Their Heterocyclic Derivatives as Potential Antimicrobial Agents: A Review.

Author(s): Arun Kumar, Vinita Gupta, Sanchita Singh, Y.K. Gupta

DOI: 10.5958/0974-4150.2017.00038.4         Access: Open Access Read More

Phytochemical, Pharmacological and Therapeutic Potential of Hordeum vulgare Linn. - A Review

Author(s): Anshul Sinha, A. K. Meena, P. Panda, Bhavana Srivastava, M. D. Gupta, M. M. Padhi

DOI:         Access: Open Access Read More

Review on Discovery Studio: An important Tool for Molecular Docking

Author(s): Shravani S. Pawar, Sachin H. Rohane

DOI: 10.5958/0974-4150.2021.00014.6         Access: Open Access Read More

A Review on Recent Trends in the Bioactive Studies of Pyrazole Derivatives

Author(s): Maddineni Aruna Kumari, Chunduri Venkatarao

DOI: 10.5958/0974-4150.2020.00072.3         Access: Open Access Read More

Studies on the Pollution Potential of Vaigai River at Madurai, India

Author(s): C.Balamurugan, L. Leena Hebsibai

DOI:         Access: Open Access Read More

Synthesis, characterization and anti-inflammatory activity some 1-(4-substituted)-2-(-4-(piperazine-1-yl) bis-thiazole-5-yl) 2-methyl-4-nitro-1h-imidazole-1-yl) ethanone

Author(s): Aejaz Ahmed, Khurshid I. Molvi, Gulam Javed Khan

DOI: 10.5958/0974-4150.2017.00027.X         Access: Open Access Read More

Prodrug as a chemical delivery system: A Review

Author(s): Alka Verma, Bhupesh Verma, Sunil Kumar Prajapati, Kishu Tripathi

DOI:         Access: Open Access Read More

Synthesis and Biological Activities of Some Benzothiazole Derivatives

Author(s): Hunasnalkar Shivraj G, Shaikh Gazi, Patil SM, Surwase Ulhas S

DOI:         Access: Open Access Read More

Antibacterial Screening of Clerodendrum infortunatum leaves: Experimental and Molecular docking studies

Author(s): Sindhu. T. J, Akhilesh K. J, Anju. Jose, Binsiya K. P, Blessy Thomas, Elizabeth Wilson

DOI: 10.5958/0974-4150.2020.00026.7         Access: Open Access Read More

Synthesis, characterization and pharmacological evaluation of novel spiro heterocyclic compounds as anti diabetic agents

Author(s): K. Kishore Kumar, R.S.K. Sharma, P. Chanti Babu, M. Sreenivasa Rao, K. Durga Prasadu, D. Ravi Kumar

DOI: 10.5958/0974-4150.2017.00067.0         Access: Open Access Read More

Physicochemical and Heavy Metal Analysis of Pond Water Quality of Mau-Aima Vicinity, Allahabad (India)

Author(s): Mohammad Rehan, Dhirendra Kumar Bharati, Sushmita Banerjee, Ravindra Kumar Gautam, Mahesh Chandra Chattopadhyaya

DOI: 10.5958/0974-4150.2017.00005.0         Access: Open Access Read More

Synthesis, Spectral, Antibacterial, Antifungal and Anticancer activity Studies of Schiff bases Derived from O-Vanillin and Aminoquinolines

Author(s): S. N. Battin, A. H. Manikshete, S. K. Sarasamkar, M. R. Asabe, D. J. Sathe

DOI: 10.5958/0974-4150.2017.00112.2         Access: Open Access Read More

Therapeutic Importance of Benzothiazole: Review

Author(s): Gupta Akhilesh, Rawat Swati

DOI:         Access: Open Access Read More

Comparative Preliminary Phytochemical and HPTLC Fingerprint profile Studies of two Cinnamon Species Commonly used in ASU Formulations

Author(s): Ajay Kumar Meena, Ch. V. Narasimhaji, P. Rekha, D. Velvizhi, R. Ilavarasan

DOI: 10.5958/0974-4150.2018.00062.7         Access: Open Access Read More

Phyto-Physico chemical evaluation, Antioxidant activities and Diuretic activity of Leaves of Lagerstroemia reginae

Author(s): S Kalidas, B Kameswari, P Devi, B Madhumitha, R Meera, NJ Merlin

DOI:         Access: Open Access Read More

Synthetic and Pharmacological Evaluation of Some Pyridine Containing Thiazolidinones

Author(s): Firke SD, Firake BM, Chaudhari RY, Patil VR

DOI:         Access: Open Access Read More

In vitro pharmacological activity of the whole plant Naregamia alata

Author(s): Sonu Jacob, Anil John J., Leena Thomas, Sabulal B.

DOI:         Access: Open Access Read More

Efficiency of AUTODOCK: Insilico study of Pharmaceutical Drug Molecules

Author(s): Uday M. Satpute, Sachin H. Rohane

DOI: 10.5958/0974-4150.2021.00016.X         Access: Open Access Read More

Asian Journal of Research in Chemistry (AJRC) is an international, peer-reviewed journal devoted to pure and applied chemistry..... Read more >>>

RNI: Not Available                     
DOI: 10.5958/0974-4150 

Quick Links

Latest Issues

Popular Articles


Recent Articles



Activated carbon from macadamia nutshells for removal of p-Nitrophenol from real wastewater: Thermodynamic evaluation
Review on Colon Targeted Drug Delivery System
Exploring the Effects of Polyacrylic Acid on Triton-X-100 Aqueous Solutions: Density, Viscosity and Ultrasonic Velocity Analysis
Formulation and Evaluation of Amaranthus dubius herbal gel
Estimation of Imatinib Mesylate by Extractive Colorimetric Methods in Bulk and Pharmaceutical Dosage Form
Qualitative and Quantitative Analysis of the Phytochemicals in Aerva lanata
Co-Solvent effect and Kinetics of Alkaline Hydrolysis of Butyle Salicylate
A Systematic Review on Ethnobotanical and Pharmacological Aspects of Croton plant Codiaeum variegatum (L.)
Review on Thiazolo-Triazole as a Promising Anticancer agent
Inimical effects of Monosodium Glutamate on various systems
Synthesis and Surface properties of LABSA Based detergents: An Ecofriendly Approach
A mini Review on Analytical and Bioanlytical Techniques in Study of Drugs-Protein Interaction
Review on Vesicular Drug Delivery System: Aquasomes
Synthesis, Characterization and Antioxidant Activity of some New Antipyrine derived Schiff Bases
Determination of Imatinib mesylate from Pharmaceutical Dosage Form by extractive ion pair complex colorimetric Method
Coupling of Single-Stranded poly-T DNA with Small Heterocyclic compounds via Peptide Linkage
Determination of Methdilazine by Extractive Colorimetric Method from Pharmaceutical Dosage Form
Synthesis and Surface properties of AOS Based detergents: A Green Synthetic approach
Bioanalytical Method Development and Validation of UV Spectrophotometric Method for Estimation of Metformin Hydrochloride in Urine Sample
Oxovanadium (IV) Complexes of α-Amino Acid Schiff Bases and 2,2

Tags


About Journal

Asian Journal of Research in Chemistry (AJRC) (ISSN: print-0974-4169, Online-0974-4150) is an international, peer-reviewed journal devoted to pure and applied chemistry. AJRC publishes Original Research Articles, Short Communications, Review Articles in all aspects of chemistry. Topics covered including the traditional areas of analytical, inorganic, organic, biochemistry, forensic, physical-theoretical chemistry as well as newer interdisciplinary areas such as agriculture, materials science, computational, medicine, spectroscopy, polymers, supramolecular, surface, chemical physics, biological, medicinal/ drugs, environmental and pharmaceutical chemistry.
The journal is published quarterly every year in last week of March, June, September and December. From January 2011, is monthly and shall be published every year in last week of Month.    
Read More  

Visitors

Today: 1506
Yesterday: 1437
Total: 1604272