ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Hitesh K. Barot, Gali Vidyasagar, Sutariya Bhavin, Shah Jignesh

Email(s): galividyasagar@gmail.com

DOI: Not Available

Address: Hitesh K. Barot1*, Gali Vidyasagar1, Sutariya Bhavin2 and Shah Jignesh2
1Department of Pharmaceutical Chemistry, Veerayatan Institute of Pharmacy, Jakhaniya, Bhuj-Mandvi Road, Kutch, Gujarat, India
2S.J.Thakkar Pharmacy College, Avadh Road, Rajkot, Gujarat, India
*Corresponding Author

Published In:   Volume - 3,      Issue - 4,     Year - 2010


ABSTRACT:
An attempt was made to synthesize new substituted thiophenes as anti-inflammatory agent, adapting Gewald reaction. A new series of compounds were synthesized from 2-amino-N-(3-chloro-4-fluorophenyl)thiophene-3-carboxamide and the required aryl aldehydes to yield seven new Schiff bases. The structures of new compounds were established on the basis of spectral and elemental analysis. The title compound were screened for anti-inflammatory, anti-bacterial and anti-oxidant activity by serum albumin protein denaturation method, agar diffusion method and ferric ion reduction method respectively. Most of the compounds have shown promising activity.


Cite this article:
Hitesh K. Barot, Gali Vidyasagar, Sutariya Bhavin, Shah Jignesh. Synthesis of Thiophene Compounds of Pharmacological Interest. Asian J. Research Chem. 3(4): Oct. - Dec. 2010; Page 1065-1068.


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