Harsha Tripathy, Krishananand ST, Laxmi Adhikary, Chandrashekhar J
Harsha Tripathy1*, Krishananand ST1, Laxmi Adhikary2 and Chandrashekhar J1
1Govt. College of Pharmacy, Bangalore, Karnataka, India
2 Biocon Limited, Hebbagodi, Bangalore, Karnataka, India
Volume - 4,
Issue - 1,
Year - 2011
In the present study we have synthesized N-substituted imidazoles following a novel N-alkylation method using domestic microwave oven. Tetra substituted imidazoles are synthesized following two step method where tri-substituted imidazoles are synthesized in the first step followed by by N-alkylation of the synthesized compounds.
These reactions present noteworthy advantages over those carried out by employing conventional heating. This method is efficient, clean and economical and the compounds synthesized showed good yield, purity and shorter reaction times. The synthesized compounds showed good anti-inflammatory activity when given orally.
Cite this article:
Harsha Tripathy, Krishananand ST, Laxmi Adhikary, Chandrashekhar J. Microwave assisted N-Alkylation of Imidazole Derivatives and Evaluation of their Antiinflammatory Activity. Asian J. Research Chem. 4(2): February 2011; Page 231-236.