ISSN

0974-4150 (Online)
0974-4169 (Print)


Author(s): Sharma Bindiya, Jain Anamika, Sharma Dipak, Dubey Arti

Email(s): bindiya12july@yahoo.com

DOI: Not Available

Address: Sharma Bindiya1, Jain Anamika2, Sharma Dipak3 and Dubey Arti4
1Dept. of Engineering Chemistry, Chameli Devi Group of Institutions, Indore (MP), India
2Dept. of Chemistry, Mata Jigabai Govt. Post Graduate Girls' College, Indore (MP), India
3Dept. of Chemical Sciences, Mahahraja Ranjit Singh College, Indore (MP), India
*Corresponding Author

Published In:   Volume - 4,      Issue - 10,     Year - 2011


ABSTRACT:
Heterofused pyrazolopyrimidines possesses various biological activities such as CNS depressant, neuroleptic, tuberculostatic, antimicrobial, adenosine receptor antagonistic, antinociceptive, anti-inflammatory, non-narcotic analgesic, anticancer and leishmanicidal activity. Therefore, in this work, we have synthesized some new Heterofused containing disubstitued Pyrazolopyrimidines employing microwave techniques and have been evaluated for their antimicrobial activity. Substituted 5-amino-1-Phenyl Pyrazole-4-Carboxamide was reacted with appropriate amount of Ethyl formate in the presence of Sodium ethoxide solution to furnish titled compounds. Neat reactants were cyclocondensed under microwaves to afford, in good yield, the desired product in less irradiation times as compared to the classical technique. All the synthesized compounds were characterized by melting point, Rf value and further confirmed by UV, IR, H1NMR and Mass spectroscopy. The title compounds were screened for antibacterial activity by cup plate method using Streptomycin as the standard drug against Klebsiella (Gram –ve), Escherichia coli (Gram –ve), Staphylococcus aureus (Gram +ve) and Bacillus subtillis (Gram +ve). All the compounds showed weak to moderate activity against all four microorganisms.


Cite this article:
Sharma Bindiya, Jain Anamika, Sharma Dipak, Dubey Arti. Microwave Assisted Improved Synthesis of Some Novel Heterofused Pyrazolopyrimidines Derivatives and Their Antimicrobial Activity. Asian J. Research Chem. 4(10): Oct., 2011; Page 1616-1620.

Cite(Electronic):
Sharma Bindiya, Jain Anamika, Sharma Dipak, Dubey Arti. Microwave Assisted Improved Synthesis of Some Novel Heterofused Pyrazolopyrimidines Derivatives and Their Antimicrobial Activity. Asian J. Research Chem. 4(10): Oct., 2011; Page 1616-1620.   Available on: https://ajrconline.org/AbstractView.aspx?PID=2011-4-10-28


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DOI: 10.5958/0974-4150 

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